Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GLS | O94925 | 3/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | PRKACG | P22612 | 1/20 | 0.43 |
| ▸ | PRKACB | P22694 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | GRK6 | P43250 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14256403 | 0.84 | HTT (0.68) | HTTTSHRKMT2AMEN1GLS | |
| SCHEMBL19920010 | 0.83 | HTT (0.60) | HTTTSHRKMT2AMEN1GLS | |
| SCHEMBL14987117 | 0.80 | HTT (0.63) | HTTTSHRKMT2AMEN1GLS | |
| SCHEMBL13933220 | 0.78 | HTT (0.60) | HTTTSHRKMT2AMEN1GLS | |
| SCHEMBL110733 | 0.76 | HTT (0.59) | HTTTSHRKMT2AMEN1GLS | |
| SCHEMBL14987118 | 0.76 | HTT (0.59) | HTTTSHRKMT2AMEN1GLS | |
| SCHEMBL29809114 | 0.76 | HTT (0.59) | HTTTSHRKMT2AMEN1GLS | |
| SCHEMBL27729369 | 0.76 | HTT (0.63) | HTTTSHRKMT2AMEN1GLS | |
| SCHEMBL8404968 | 0.75 | CYP11B1 (0.67) | MAPTCYP11B1CYP11B2 | |
| SCHEMBL15081591 | 0.75 | HTT (0.61) | HTTTSHRKMT2AMEN1GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103003266-A | Hydroxyalkylbenzylpyrazoles and their use for the treatment of hyperproliferative and angiogenic diseases | BAYER IP GMBH | 2013-03-27 | — | — | CN | disclosed |
| EP-2569309-A1 | HYDROXYALKYL BENZYL PYRAZOLES, AND USE THEREOF FOR THE TREATMENT OF HYPERPROLIFERATIVE AND ANGIOGENIC DISEASES | Bayer Intellectual Property GmbH (DE) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011141325-A1 | HYDROXYALKYL BENZYL PYRAZOLES, AND USE THEREOF FOR THE TREATMENT OF HYPERPROLIFERATIVE AND ANGIOGENIC DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2011-11-17 | — | — | WO | disclosed |