Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CCL2 | P13500 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15987500 | 0.74 | HTR2A (0.38) | HTR2AHTR6PARP1KDM4ETP53 | |
| SCHEMBL13782351 | 0.74 | HTR2A (0.38) | HTR2AHTR6PARP1KDM4ETP53 | |
| SCHEMBL8285073 | 0.74 | BRD4 (0.38) | HTR2AHTR6PARP1KDM4ETP53 | |
| SCHEMBL13782587 | 0.74 | HTR2A (0.38) | HTR2AHTR6PARP1KDM4ETP53 | |
| SCHEMBL4295538 | 0.74 | HTR2A (0.38) | HTR2AHTR6PARP1KDM4ETP53 | |
| SCHEMBL10578702 | 0.74 | HTR2A (0.38) | HTR2AHTR6PARP1KDM4ETP53 | |
| SCHEMBL31072716 | 0.71 | PRCP (0.43) | HTR2APARP1KDM4ECYP3A4MEN1 | |
| SCHEMBL22345616 | 0.71 | PRCP (0.43) | HTR2APARP1KDM4ECYP3A4MEN1 | |
| SCHEMBL29768304 | 0.70 | PRCP (0.45) | HTR2APARP1KDM4EALDH1A1HTR2C | |
| SCHEMBL28774779 | 0.70 | PRCP (0.45) | HTR2APARP1KDM4EALDH1A1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106536502-B | The phenyl tetrahydro isoquinoline compound being substituted by heteroaryl | 大正制药株式会社 | 2019-03-05 | — | — | CN | disclosed |
| EP-3173408-B1 | PHENYL TETRAHYDROISOQUINOLINE COMPOUND SUBSTITUTED WITH HETEROARYL | TAISHO PHARMACEUTICAL CO LTD (JP) | 2018-11-21 | — | — | EP | disclosed |
| US-9932331-B2 | Phenyl tetrahydroisoquinoline compound substituted with heteroaryl | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2018-04-03 | — | — | US | disclosed |
| US-20170210736-A1 | PHENYL TETRAHYDROISOQUINOLINE COMPOUND SUBSTITUTED WITH HETEROARYL | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2017-07-27 | — | — | US | disclosed |
| EP-3173408-A1 | PHENYL TETRAHYDROISOQUINOLINE COMPOUND SUBSTITUTED WITH HETEROARYL | Taisho Pharmaceutical Co., Ltd. (JP) | 2017-05-31 | — | — | EP | disclosed |
| CN-106536502-A | Phenyl tetrahydroisoquinoline compound substituted with heteroaryl | 大正制药株式会社 | 2017-03-22 | — | — | CN | disclosed |
| EP-2569298-A1 | NOVEL CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | Boehringer Ingelheim International GmbH (DE) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011141474-A1 | NOVEL CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-17 | — | — | WO | disclosed |
| WO-2004019986-A1 | METHODS OF TREATING ACUTE RESPIRATORY DISTRESS SYNDROME | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170210736-A1 | PHENYL TETRAHYDROISOQUINOLINE COMPOUND SUBSTITUTED WITH HETEROARYL | NHERF1, SLC9A3, SLC26A3 | HTR2A 2248/4885HTR6 1201/4885PARP1 3132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.