Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | DRD4 | P21917 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1948541 | 0.89 | FNTA (0.39) | MEN1KMT2ADRD2DRD4ALDH1A1 | |
| SCHEMBL1951261 | 0.88 | DRD2 (0.38) | MEN1KMT2ADRD2DRD4ALDH1A1 | |
| SCHEMBL1948644 | 0.83 | FNTA (0.39) | MEN1KMT2ADRD2DRD4ALDH1A1 | |
| SCHEMBL1949522 | 0.82 | LMNA (0.42) | MEN1KMT2AALDH1A1GAACNR1 | |
| SCHEMBL1949362 | 0.81 | LMNA (0.45) | MEN1KMT2AALDH1A1GAACNR1 | |
| SCHEMBL1951421 | 0.79 | LMNA (0.43) | MEN1KMT2AALDH1A1CNR2OXTR | |
| SCHEMBL1948479 | 0.79 | MEN1 (0.41) | MEN1KMT2ACNR1CNR2OXTR | |
| SCHEMBL3281840 | 0.79 | KMT2A (0.51) | MEN1KMT2AALDH1A1CNR1CNR2 | |
| SCHEMBL1949371 | 0.78 | NOTUM (0.47) | KMT2ADRD2DRD4ALDH1A1GAA | |
| SCHEMBL1951593 | 0.78 | LMNA (0.42) | MEN1KMT2AALDH1A1GAACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438055-A1 | DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139967-A1 | DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2010-12-09 | — | — | WO | disclosed |