Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26415357 | 0.84 | SMN1; SMN2 (0.35) | MAPTSMN1; SMN2HSD17B10KDM4EALDH1A1 | |
| SCHEMBL26412339 | 0.80 | HSD17B10 (0.34) | MAPTAPPSMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL26415363 | 0.75 | PLA2G2A (0.39) | MAPTSMN1; SMN2HSD17B10KDM4EALDH1A1 | |
| SCHEMBL2635623 | 0.69 | LMNA (0.51) | MAPTHSD17B10KDM4EALDH1A1GAA | |
| SCHEMBL25934600 | 0.68 | HSD17B10 (0.34) | MAPTAPPSMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL26020287 | 0.68 | HSD17B10 (0.34) | MAPTAPPSMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL26020502 | 0.67 | CYP1A2 (0.34) | MAPTAPPSMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL15784496 | 0.67 | MAPK1 (0.39) | HSD17B10KDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL2904899 | 0.67 | EGFR (0.46) | EGFRNR4A2ABL1RXFP1MRGPRX4 | |
| SCHEMBL13837541 | 0.66 | MAPK1 (0.38) | SMN1; SMN2HSD17B10KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230130109-A1 | MACROCYCLIC INDOLE DERIVATIVES AS INHIBITORS OF MCL-1 | JANSSEN PHARMACEUTICA NV (BE) | 2023-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230130109-A1 | MACROCYCLIC INDOLE DERIVATIVES AS INHIBITORS OF MCL-1 | MCL1, BCL2L1, BAK1 | MAPT 3113/4885APP 2775/4885SMN1; SMN2 2915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.