Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.60 |
| ▸ | TACR2 | P21452 | 1/20 | 0.60 |
| ▸ | DRD1 | P21728 | 1/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | GALE | Q14376 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3737958 | 0.78 | NR1I2 (0.60) | NR1I2ADRA2AADORA3ADRA2BADRA2C | |
| SCHEMBL2641277 | 0.78 | TDP1 (0.56) | TSHRTDP1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL22558160 | 0.78 | NR1I2 (0.46) | NR1I2ADRA2AADORA3ADRA2BADRA2C | |
| SCHEMBL11331289 | 0.78 | ALDH1A1 (0.45) | LMNATSHRTDP1ALDH1A1RAB9A | |
| Haloprogin SCHEMBL30128207 | 0.75 | NR1I2 (1.00) | NR1I2ADRA2AADORA3ADRA2BADRA2C | |
| Haloprogin SCHEMBL3649 | 0.75 | NR1I2 (1.00) | NR1I2ADRA2AADORA3ADRA2BADRA2C | |
| SCHEMBL14529596 | 0.75 | NR1I2 (0.67) | NR1I2ADRA2AADORA3ADRA2BADRA2C | |
| Haloprogin SCHEMBL8165340 | 0.75 | NR1I2 (1.00) | NR1I2ADRA2AADORA3ADRA2BADRA2C | |
| SCHEMBL96506 | 0.72 | MEN1 (0.47) | LMNATSHRTDP1L3MBTL1MAPT | |
| SCHEMBL978758 | 0.72 | NR1I2 (0.52) | NR1I2ADRA2AADORA3ADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105777640-B | Pyrazole cyclohexanediol ether compound and application thereof | 沈阳中化农药化工研发有限公司 | 2020-01-07 | — | — | CN | claimed |
| CN-105777640-A | Pyrazole cyclohexanediol ether compounds and applications thereof | 沈阳中化农药化工研发有限公司 | 2016-07-20 | — | — | CN | claimed |
| EP-0675895-B1 | ETOPOSIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS A DRUG AND IN THE PREPARATION OF A DRUG FOR TREATING CANCER | PF MEDICAMENT (FR) | 1997-07-23 | — | — | EP | claimed |
| US-5643885-A | Etoposide derivatives, process for preparing them, their use as a medicinal product and their use for the preparation of a medicinal product intended for anti-cancer treatment | PIERRE FABRE MEDICAMENT (FR) | 1997-07-01 | — | — | US | claimed |
| JP-H08504795-A | — | — | 1996-05-21 | — | — | JP | claimed |
| EP-0675895-A1 | ETOPOSIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS A DRUG AND IN THE PREPARATION OF A DRUG FOR TREATING CANCER. | FABRE PIERRE COSMETIQUE (FR) | 1995-10-11 | — | — | EP | claimed |
| WO-1994014829-A1 | ETOPOSIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS A DRUG AND IN THE PREPARATION OF A DRUG FOR TREATING CANCER | PIERRE FABRE MEDICAMENT (FR) | 1994-07-07 | — | — | WO | claimed |
| CN-114206831-A | Conjugates of auxin analogs | 以色列国家农业部、农村发展农业研究组织·沃尔卡尼中心 | 2022-03-18 | — | — | CN | disclosed |
| EP-3956294-A1 | CONJUGATES OF AUXIN ANALOGS | The State of Israel, Ministry of Agriculture and Rural Development, Agricultural Research Organization (ARO) (Volcani Center) (IL) | 2022-02-23 | — | — | EP | disclosed |
| US-20220030866-A1 | CONJUGATES OF AUXIN ANALOGS | THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (IL) | 2022-02-03 | — | — | US | disclosed |
| WO-2020212993-A1 | CONJUGATES OF AUXIN ANALOGS | THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (ARO) (VOLCANI CENTER) (IL) | 2020-10-22 | — | — | WO | disclosed |
| CN-105777640-B | Pyrazole cyclohexanediol ether compound and application thereof | 沈阳中化农药化工研发有限公司 | 2020-01-07 | — | — | CN | disclosed |
| CN-105777640-A | Pyrazole cyclohexanediol ether compounds and applications thereof | 沈阳中化农药化工研发有限公司 | 2016-07-20 | — | — | CN | disclosed |
| US-6750344-B1 | MONOCYCLIC AMINE SCAFFOLD BEARING AT LEAST TWO SITES OF DIVERSITY, CYCLIZED TO FORM BICYCLIC AMINE SCAFFOLDS; 7-AMINO-PYRROLO(1,2-A)PYRAZIN-4-ONE COMPOUNDS | ISIS PHARMACEUTICALS, INC. | 2004-06-15 | — | — | US | disclosed |
| US-6559303-B1 | Bridgehead atoms are bonded to one or more bridges that interconnect one or more ring systems thereby forming a large cyclic structure. Located in each bridge are two or more nitrogenous moieties that are derivatized with chemical | ISIS PHARMACEUTICALS, INC. | 2003-05-06 | — | — | US | disclosed |
| EP-0675895-B1 | ETOPOSIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS A DRUG AND IN THE PREPARATION OF A DRUG FOR TREATING CANCER | PF MEDICAMENT (FR) | 1997-07-23 | — | — | EP | disclosed |
| US-5643885-A | Etoposide derivatives, process for preparing them, their use as a medicinal product and their use for the preparation of a medicinal product intended for anti-cancer treatment | PIERRE FABRE MEDICAMENT (FR) | 1997-07-01 | — | — | US | disclosed |
| EP-0675895-A1 | ETOPOSIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS A DRUG AND IN THE PREPARATION OF A DRUG FOR TREATING CANCER. | FABRE PIERRE COSMETIQUE (FR) | 1995-10-11 | — | — | EP | disclosed |
| WO-1994014829-A1 | ETOPOSIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS A DRUG AND IN THE PREPARATION OF A DRUG FOR TREATING CANCER | PIERRE FABRE MEDICAMENT (FR) | 1994-07-07 | — | — | WO | disclosed |
| US-4349488-A | Process for producing esters of 3,5-dibromo-4-hydroxybenzonitrile | GREAT LAKES CHEMICAL CORPORATION (US) | 1982-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220030866-A1 | CONJUGATES OF AUXIN ANALOGS | CROCC, CCNY, AGXT | NR1I2 1744/4885ADRA2A 1436/4885ADORA3 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.