Haloprogin

Haloprogin

SCHEMBL3649

Clc1cc(Cl)c(OCC#CI)cc1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1I2 O75469 1/20 1.00
ADRA2A P08913 1/20 1.00
ADORA3 P0DMS8 1/20 1.00
ADRA2B P18089 1/20 1.00
ADRA2C P18825 1/20 1.00
TACR2 P21452 1/20 1.00
DRD1 P21728 1/20 1.00
SLC6A2 P23975 1/20 1.00
HTR2A P28223 1/20 1.00
HTR2C P28335 1/20 1.00
ADORA1 P30542 1/20 1.00
SLC6A4 P31645 1/20 1.00
OPRM1 P35372 1/20 1.00
DRD3 P35462 1/20 1.00
OPRK1 P41145 1/20 1.00
HTR6 P50406 1/20 1.00
SLC6A3 Q01959 1/20 1.00
KCNH2 Q12809 1/20 1.00
GALE Q14376 1/20 1.00
LMNA P02545 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Haloprogin SCHEMBL30128207 1.00 NR1I2 (1.00) NR1I2ADRA2AADORA3ADRA2BADRA2C
Haloprogin SCHEMBL8165340 1.00 NR1I2 (1.00) NR1I2ADRA2AADORA3ADRA2BADRA2C
Haloprogin SCHEMBL5528345 0.88 NR1I2 (0.78) NR1I2ADRA2AADORA3ADRA2BADRA2C
SCHEMBL14529596 0.80 NR1I2 (0.67) NR1I2ADRA2AADORA3ADRA2BADRA2C
Disulfiram SCHEMBL5306580 0.79 ADRA2A (0.62) NR1I2ADRA2AADORA3ADRA2BADRA2C
SCHEMBL2641377 0.75 NR1I2 (0.60) NR1I2ADRA2AADORA3ADRA2BADRA2C
SCHEMBL3737958 0.75 NR1I2 (0.60) NR1I2ADRA2AADORA3ADRA2BADRA2C
Haloprogin SCHEMBL21327043 0.74 NR1I2 (0.56) NR1I2ADRA2AADORA3ADRA2BADRA2C
SCHEMBL11307723 0.74 NR1I2 (0.58) NR1I2ADRA2AADORA3ADRA2BADRA2C
SCHEMBL978758 0.69 NR1I2 (0.52) NR1I2ADRA2AADORA3ADRA2BADRA2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 9636 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
US-20260027140-A1 COMPOSITIONS AND METHODS FOR TREATING AND AMELIORATING RESPIRATORY CONDITIONS AND INFLAMMATION OF MUCOSA ATOPIC MEDICAL INC (US) 2026-01-29 US claimed
EP-4680240-A1 METHOD OF TREATING DISORDERS WITH SURF1 MALFUNCTION Cure Mito Foundation (US) 2026-01-21 EP claimed
EP-4676500-A2 MICROBIAL CONSORTIA Kanvas Biosciences, Inc (US) 2026-01-14 EP claimed
US-20250268998-A1 METHODS OF TREATMENT FOR CANDIDA AURIS INFECTIONS LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER 2025-08-28 US claimed
US-20250248940-A1 Biopolymer Formulations for Drug Delivery 11584022 CANADA INC. (CA) 2025-08-07 US claimed
US-12324830-B2 Methods of treatment for Candida auris infections LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER 2025-06-10 US claimed
EP-4547280-A1 BIOPOLYMER FORMULATIONS FOR DRUG DELIVERY 11584022 Canada Inc. (CA) 2025-05-07 EP claimed
WO-2025080590-A1 CO-CRYSTALLIZATION OF ACTIVES WITH SACCHARIDE-BASED MOLECULAR FRAMEWORKS SCIENTIFIC HORIZONS CONSULTING LLC (US) 2025-04-17 WO claimed
US-12274830-B2 Nitric oxide inhalation therapy for infants with bronchiolitis BEYOND AIR LTD (IL) 2025-04-15 US claimed
US-4895727-A Using water soluble zinc compound CHEMEX PHARMACEUTICALS, INC. (US) 1990-01-23 US claimed
EP-0320254-A1 Aqueous gels containing topical medicaments THAMES PHARMACAL CO.INC. (US) 1989-06-14 EP claimed
EP-0098743-B1 PHENYL ALPHA-ACYLOXYACETAMIDE DERIVATES AND THEIR THERAPEUTIC USE Yu, Ruey J., Dr. (US) 1988-09-28 EP claimed
EP-0273202-A2 Use of hydroxycarboxylic acids to enhance therapeutic effects of topical compositions for fungal infections and pigmented spots. Van Scott, Eugene J., Dr. (US) 1988-07-06 EP claimed
EP-0094329-B1 TANNING PROCESS FOR RENDERING LEATHERS MYCOSTATIC, ANTIMYCOSIC AND ANTIFUNGICIDAL, AND ARTICLES PRODUCED THEREBY Roux, Joel (FR) 1986-01-22 EP claimed
US-4518789-A Phenyl alpha-acyloxyacetamide derivatives and their therapeutic use YU RUEY J 1985-05-21 US claimed
US-4484925-A USING BIOCIDAL AGENTS ON METAL COMPLEXES ROUX JOEL (FR) 1984-11-27 US claimed
US-4434183-A 3-IODO-2-PROPYNYL 2,4,5-TRICHLOROPHENYL ETHER PENNWALT CORPORATION (US) 1984-02-28 US claimed
EP-0098743-A1 Phenyl alpha-acyloxyacetamide derivates and their therapeutic use Yu, Ruey J., Dr. (US) 1984-01-18 EP claimed
EP-0094329-A1 Tanning process for rendering leathers mycostatic, antimycosic and antifungicidal, and articles produced thereby Roux, Joel (FR) 1983-11-16 EP claimed