Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 2/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | PTAFR | P25105 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8386277 | 0.78 | QDPR (0.53) | QDPRNOTUMNAMPTPTAFRCYP1A2 | |
| SCHEMBL8261115 | 0.78 | QDPR (0.49) | QDPRNOTUMNAMPTPTAFRCYP1A2 | |
| SCHEMBL3307094 | 0.77 | QDPR (0.50) | QDPRNOTUMNAMPTPTAFRCYP1A2 | |
| SCHEMBL18611164 | 0.76 | QDPR (0.47) | QDPRNOTUMNAMPTPTAFRCYP1A2 | |
| SCHEMBL13804073 | 0.76 | QDPR (0.47) | QDPRNOTUMNAMPTPTAFRCYP1A2 | |
| SCHEMBL14028045 | 0.75 | PDK4 (0.50) | NAMPTSMN1; SMN2 | |
| SCHEMBL11560724 | 0.74 | QDPR (0.46) | QDPRNOTUMPTAFRTSHRKMT2A | |
| SCHEMBL13851469 | 0.74 | QDPR (0.46) | QDPRNOTUMNAMPTPTAFRCYP1A2 | |
| SCHEMBL10412647 | 0.73 | QDPR (0.45) | QDPRNOTUMNAMPTPTAFRCYP1A2 | |
| SCHEMBL104852 | 0.73 | QDPR (0.45) | QDPRNOTUMNAMPTPTAFRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675858-B1 | IMIDAZO[1,5-A]PYRAZINE COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION | OPTIKIRA LLC (US) | 2023-04-26 | — | — | EP | disclosed |