Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
| ▸ | GABRE | P78334 | 1/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.37 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.37 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13804073 | 0.86 | QDPR (0.47) | QDPRNOTUMPTAFRBPTF | |
| SCHEMBL28275844 | 0.84 | TSHR (0.39) | TSHRLMNAGABRPGABRDGABRA1 | |
| SCHEMBL11580323 | 0.80 | CYP2C19 (0.38) | TSHRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL11554285 | 0.78 | MAPT (0.42) | TSHRLMNAKMT2A | |
| SCHEMBL8261115 | 0.76 | QDPR (0.49) | QDPRNOTUMLMNAPTAFR | |
| SCHEMBL8386277 | 0.76 | QDPR (0.53) | QDPRNOTUMLMNAPTAFRKMT2A | |
| SCHEMBL3841650 | 0.76 | QDPR (0.43) | QDPRTSHRLMNAGABRPGABRD | |
| SCHEMBL17356917 | 0.75 | PKM (0.54) | LMNAGABRDGABRA1GABRB1GABRA5 | |
| Hydrochloric Acid SCHEMBL9704069 | 0.74 | QDPR (0.42) | QDPRTSHRLMNAGABRPGABRD | |
| SCHEMBL18611164 | 0.74 | QDPR (0.47) | QDPRNOTUMLMNAPTAFRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000167-A1 | 1,2,3,6-Tetrahydroisonicotinic acid and derivatives thereof, methods and starting products for their preparation, and pharmaceutical compositions containing them. | Krogsgaard-Larsen, Povl (DK) | 1979-01-10 | — | — | EP | disclosed |