Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 9/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1949371 | 0.97 | NOTUM (0.47) | NOTUMLMNATHRBNPY2RPOLB | |
| SCHEMBL1950702 | 0.92 | NOTUM (0.47) | NOTUMLMNATHRBPOLBMAPT | |
| SCHEMBL1948520 | 0.86 | ALDH1A1 (0.36) | NOTUMTHRBNPY2RGAADRD2 | |
| SCHEMBL1947007 | 0.86 | DRD2 (0.40) | NOTUMLMNAGAADRD2DRD4 | |
| SCHEMBL1950696 | 0.85 | DRD2 (0.39) | NOTUMLMNATHRBPOLBMAPT | |
| SCHEMBL1951599 | 0.81 | DRD2 (0.40) | NOTUMLMNATHRBGAADRD2 | |
| SCHEMBL1950166 | 0.81 | PTPN11 (0.43) | LMNATHRBPOLBMAPTGAA | |
| SCHEMBL1949755 | 0.81 | DRD4 (0.43) | NOTUMLMNATHRBPOLBMAPT | |
| SCHEMBL1950714 | 0.80 | DRD2 (0.42) | LMNATHRBPOLBMAPTGAA | |
| SCHEMBL1948760 | 0.78 | CNR2 (0.36) | LMNAPOLBGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438055-A1 | DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139967-A1 | DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2010-12-09 | — | — | WO | disclosed |