Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.52 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1060874 | 0.89 | GPR119 (0.53) | GPR119 | |
| SCHEMBL1059030 | 0.87 | GPR119 (0.70) | GPR119SSTR4PSEN1PSEN2APH1B | |
| SCHEMBL8514711 | 0.86 | GPR119 (0.43) | GPR119SSTR4CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL8514825 | 0.86 | GPR119 (0.43) | GPR119SSTR4CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL8612817 | 0.86 | GPR119 (0.43) | GPR119SSTR4CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL2641695 | 0.83 | GPR119 (0.41) | GPR119KMT2AHCRTR2JAK2 | |
| SCHEMBL2641556 | 0.83 | GPR119 (0.38) | GPR119SSTR4CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL8513541 | 0.82 | GPR119 (0.48) | GPR119KMT2APSEN1PSEN2APH1B | |
| SCHEMBL2634581 | 0.81 | GPR119 (0.58) | GPR119KMT2AJAK2 | |
| SCHEMBL2634612 | 0.81 | GPR119 (0.49) | GPR119KMT2APSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438051-A1 | L- ( PIPERIDIN-4-YL) -PYRAZOLE DERIVATIVES AS GPR 119 MODULATORS | Pfizer Inc. (US) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010140092-A1 | L- ( PIPERIDIN-4-YL) -PYRAZOLE DERIVATIVES AS GPR 119 MODULATORS | PFIZER INC. (US) | 2010-12-09 | — | — | WO | disclosed |