Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1059905 | 0.88 | GPR119 (0.47) | GPR119JAK2 | |
| SCHEMBL2635054 | 0.85 | GPR119 (0.35) | GPR119JAK2 | |
| SCHEMBL2635200 | 0.84 | GPR119 (0.41) | GPR119 | |
| SCHEMBL2641575 | 0.83 | GPR119 (0.52) | GPR119JAK2KMT2AHCRTR2 | |
| SCHEMBL2634966 | 0.78 | GPR119 (0.52) | GPR119 | |
| SCHEMBL1061706 | 0.76 | GPR119 (0.44) | GPR119JAK2KMT2AJAK1 | |
| SCHEMBL2641556 | 0.75 | GPR119 (0.38) | GPR119KMT2A | |
| SCHEMBL1059180 | 0.73 | GPR119 (0.47) | GPR119KMT2A | |
| SCHEMBL1056240 | 0.73 | GPR119 (0.55) | GPR119 | |
| SCHEMBL1060874 | 0.73 | GPR119 (0.53) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438051-A1 | L- ( PIPERIDIN-4-YL) -PYRAZOLE DERIVATIVES AS GPR 119 MODULATORS | Pfizer Inc. (US) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010140092-A1 | L- ( PIPERIDIN-4-YL) -PYRAZOLE DERIVATIVES AS GPR 119 MODULATORS | PFIZER INC. (US) | 2010-12-09 | — | — | WO | disclosed |