Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2641620 | 0.90 | GPR119 (0.53) | GPR119 | |
| SCHEMBL2641643 | 0.78 | GPR119 (0.37) | GPR119 | |
| SCHEMBL2634966 | 0.71 | GPR119 (0.52) | GPR119CYP3A4CYP2C9 | |
| SCHEMBL1060722 | 0.71 | CYP3A4 (0.41) | GPR119CYP3A4CYP2C9 | |
| SCHEMBL1060719 | 0.71 | CYP3A4 (0.41) | GPR119CYP3A4CYP2C9 | |
| SCHEMBL2641556 | 0.70 | GPR119 (0.38) | GPR119 | |
| SCHEMBL1053663 | 0.70 | GPR119 (0.56) | GPR119CYP2C9 | |
| SCHEMBL1059180 | 0.68 | GPR119 (0.47) | GPR119CYP3A4CYP2C9 | |
| SCHEMBL12961780 | 0.68 | GPR119 (0.67) | GPR119CYP3A4CYP2C9 | |
| SCHEMBL1061381 | 0.67 | GPR119 (0.56) | GPR119CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643310-A1 | 4- (5-CYANO-PYRAZOL-1-YL) -PIPERIDINE DERIVATIVES AS GPR 119 MODULATORS | Pfizer Inc (US) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012069948-A1 | 4- (5-CYANO-PYRAZOL-1-YL) -PIPERIDINE DERIVATIVES AS GPR 119 MODULATORS | PFIZER INC. (US) | 2012-05-31 | — | — | WO | disclosed |
| EP-2438051-A1 | L- ( PIPERIDIN-4-YL) -PYRAZOLE DERIVATIVES AS GPR 119 MODULATORS | Pfizer Inc. (US) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010140092-A1 | L- ( PIPERIDIN-4-YL) -PYRAZOLE DERIVATIVES AS GPR 119 MODULATORS | PFIZER INC. (US) | 2010-12-09 | — | — | WO | disclosed |