Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.63 |
| ▸ | KDR | P35968 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | DDX3X | O00571 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17079632 | 0.88 | DDX3X (0.73) | TRPV1KDRMEN1KMT2AMAPT | |
| SCHEMBL29470036 | 0.85 | KMT2A (0.67) | KDRMEN1KMT2AMAPTHTT | |
| SCHEMBL22648635 | 0.85 | TRPV1 (0.61) | TRPV1KDRMEN1KMT2AMAPT | |
| SCHEMBL26417447 | 0.85 | TRPV1 (0.63) | TRPV1KDRMEN1KMT2AMAPT | |
| SCHEMBL1463302 | 0.84 | GRIK1 (0.67) | TRPV1KDRMEN1KMT2AMAPT | |
| SCHEMBL17664319 | 0.83 | KMT2A (0.82) | TRPV1KDRMEN1KMT2AMAPT | |
| SCHEMBL26417399 | 0.83 | MEN1 (0.61) | TRPV1MEN1KMT2AMAPTRAB9A | |
| SCHEMBL30101230 | 0.82 | KMT2A (0.90) | KDRMEN1KMT2AMAPTHTT | |
| SCHEMBL5597699 | 0.82 | KMT2A (0.90) | KDRMEN1KMT2AMAPTHTT | |
| SCHEMBL19398194 | 0.82 | KDR (0.70) | TRPV1KDRMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675858-B1 | IMIDAZO[1,5-A]PYRAZINE COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION | OPTIKIRA LLC (US) | 2023-04-26 | — | — | EP | disclosed |