Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.61 |
| ▸ | RAB9A | P51151 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.61 |
| ▸ | DDX3X | O00571 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | GBA1 | P04062 | 1/20 | 0.54 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26417409 | 0.83 | TRPV1 (0.61) | MEN1KMT2ARAB9AMAPTTRPV1 | |
| SCHEMBL22648463 | 0.83 | MEN1 (0.57) | MEN1KMT2ARAB9AMAPTTRPV1 | |
| SCHEMBL22648464 | 0.83 | MEN1 (0.57) | MEN1KMT2ARAB9AMAPTTRPV1 | |
| SCHEMBL26417440 | 0.83 | TRPV1 (0.63) | MEN1KMT2ARAB9AMAPTTRPV1 | |
| SCHEMBL26417507 | 0.81 | TAAR1 (0.60) | MEN1KMT2ARAB9AMAPTTRPV1 | |
| SCHEMBL30851500 | 0.80 | RAB9A (0.79) | MEN1KMT2ARAB9AMAPTNPC1 | |
| SCHEMBL27193042 | 0.80 | RAB9A (0.79) | MEN1KMT2ARAB9AMAPTNPC1 | |
| SCHEMBL29555903 | 0.77 | RAB9A (0.69) | MEN1KMT2ARAB9AMAPTNPC1 | |
| SCHEMBL546002 | 0.77 | TRPV1 (0.66) | MEN1KMT2ARAB9AMAPTTRPV1 | |
| SCHEMBL4115751 | 0.77 | NPC1 (0.67) | MEN1KMT2ARAB9AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675858-B1 | IMIDAZO[1,5-A]PYRAZINE COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION | OPTIKIRA LLC (US) | 2023-04-26 | — | — | EP | disclosed |