Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | BCL6 | P41182 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1059433 | 0.83 | GPR119 (0.44) | GPR119 | |
| SCHEMBL2634734 | 0.80 | GPR119 (0.36) | GPR119KMT2ARAB9A | |
| SCHEMBL1061706 | 0.80 | GPR119 (0.44) | GPR119KMT2ARAB9ANPC1 | |
| SCHEMBL2641643 | 0.79 | GPR119 (0.37) | GPR119KMT2ARAB9AUSP30 | |
| SCHEMBL2641548 | 0.79 | GPR119 (0.35) | GPR119KMT2ARAB9A | |
| SCHEMBL21410806 | 0.78 | KMT2A (0.32) | KMT2ARAB9AUSP2ALDH1A1 | |
| SCHEMBL8512190 | 0.74 | ALDH1A1 (0.41) | GPR119KMT2AALDH1A1 | |
| SCHEMBL1059180 | 0.72 | GPR119 (0.47) | GPR119KMT2ARAB9A | |
| SCHEMBL1059191 | 0.69 | GPR119 (0.53) | GPR119KMT2ARAB9AALDH1A1NPC1 | |
| SCHEMBL8514864 | 0.69 | GPR119 (0.44) | GPR119ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438051-A1 | L- ( PIPERIDIN-4-YL) -PYRAZOLE DERIVATIVES AS GPR 119 MODULATORS | Pfizer Inc. (US) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010140092-A1 | L- ( PIPERIDIN-4-YL) -PYRAZOLE DERIVATIVES AS GPR 119 MODULATORS | PFIZER INC. (US) | 2010-12-09 | — | — | WO | disclosed |