Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 2/20 | 0.70 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2642015 | 1.00 | GCK (0.70) | GCKRAB9AALDH1A1KDM4ETSHR | |
| SCHEMBL2642055 | 0.83 | GCK (1.00) | GCKRAB9AKDM4EKMT2AHPGD | |
| SCHEMBL2642100 | 0.83 | GCK (1.00) | GCKRAB9AKDM4EKMT2AHPGD | |
| SCHEMBL2642006 | 0.82 | GCK (0.64) | GCKALDH1A1HPGDRARARARB | |
| SCHEMBL2642009 | 0.82 | GCK (0.64) | GCKALDH1A1HPGDRARARARB | |
| SCHEMBL2642024 | 0.79 | GCK (0.80) | GCKRAB9AKDM4EKMT2AHPGD | |
| SCHEMBL2642026 | 0.79 | GCK (0.80) | GCKRAB9AKDM4EKMT2AHPGD | |
| SCHEMBL2398634 | 0.75 | GCK (0.55) | GCKRAB9AALDH1A1KDM4EGAA | |
| SCHEMBL2398633 | 0.75 | GCK (0.55) | GCKRAB9AALDH1A1KDM4EGAA | |
| SCHEMBL14519324 | 0.72 | GCK (0.79) | GCKRAB9AALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070093535-A1 | Vinyl phenyl derivatives as GLK activators | ASTRAZENECA AB | 2007-04-26 | — | — | US | disclosed |
| US-7199140-B2 | Vinyl phenyl derivatives as GLK activators | ASTRAZENECA AB (SE) | 2007-04-03 | — | — | US | disclosed |
| EP-1406620-B1 | VINYL PHENYL DERIVATIVES AS GLK ACTIVATORS | ASTRAZENECA AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| US-20050054715-A1 | Vinyl phenyl derivatives as glk activators | ASTRAZENECA AB (SE) | 2005-03-10 | — | — | US | disclosed |
| EP-1406620-A1 | VINYL PHENYL DERIVATIVES AS GLK ACTIVATORS | Astrazeneca AB (SE) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003000262-A1 | VINYL PHENYL DERIVATIVES AS GLK ACTIVATORS | ASTRAZENECA AB (SE) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054715-A1 | Vinyl phenyl derivatives as glk activators | GCK, GCKR, GK | GCK 1/4885RAB9A 3969/4885ALDH1A1 1706/4885 |
| US-20070093535-A1 | Vinyl phenyl derivatives as GLK activators | GCK, GCKR, GK | GCK 1/4885RAB9A 3881/4885ALDH1A1 1641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.