Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 3/20 | 1.00 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.50 |
| ▸ | RXRA | P19793 | 4/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.41 |
| ▸ | RXRB | P28702 | 2/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2642055 | 1.00 | GCK (1.00) | GCKPTGER1RXRAXDHMAP4K4 | |
| SCHEMBL2642024 | 0.89 | GCK (0.80) | GCKPTGER1RXRAHPGDNPC1 | |
| SCHEMBL2642026 | 0.89 | GCK (0.80) | GCKPTGER1RXRAHPGDNPC1 | |
| SCHEMBL14519324 | 0.88 | GCK (0.79) | GCKPTGER1HPGDNPC1RAB9A | |
| SCHEMBL14519337 | 0.87 | GCK (0.76) | GCKPTGER1HPGDNPC1RAB9A | |
| SCHEMBL8675593 | 0.87 | GCK (0.76) | GCKPTGER1HPGDNPC1RAB9A | |
| SCHEMBL8321297 | 0.83 | GCK (0.71) | GCKPTGER1RXRAMAP4K4HPGD | |
| SCHEMBL8321293 | 0.83 | GCK (0.71) | GCKPTGER1RXRAMAP4K4HPGD | |
| SCHEMBL2642015 | 0.83 | GCK (0.70) | GCKPTGER1RXRAHPGDNPC1 | |
| SCHEMBL2642018 | 0.83 | GCK (0.70) | GCKPTGER1RXRAHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070093535-A1 | Vinyl phenyl derivatives as GLK activators | ASTRAZENECA AB | 2007-04-26 | — | — | US | disclosed |
| US-20070093535-A1 | Vinyl phenyl derivatives as GLK activators | ASTRAZENECA AB | 2007-04-26 | — | — | US | disclosed |
| US-20070093535-A1 | Vinyl phenyl derivatives as GLK activators | ASTRAZENECA AB | 2007-04-26 | — | — | US | disclosed |
| US-7199140-B2 | Vinyl phenyl derivatives as GLK activators | ASTRAZENECA AB (SE) | 2007-04-03 | — | — | US | disclosed |
| US-7199140-B2 | Vinyl phenyl derivatives as GLK activators | ASTRAZENECA AB (SE) | 2007-04-03 | — | — | US | disclosed |
| US-7199140-B2 | Vinyl phenyl derivatives as GLK activators | ASTRAZENECA AB (SE) | 2007-04-03 | — | — | US | disclosed |
| EP-1406620-B1 | VINYL PHENYL DERIVATIVES AS GLK ACTIVATORS | ASTRAZENECA AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| EP-1406620-B1 | VINYL PHENYL DERIVATIVES AS GLK ACTIVATORS | ASTRAZENECA AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| US-20050054715-A1 | Vinyl phenyl derivatives as glk activators | ASTRAZENECA AB (SE) | 2005-03-10 | — | — | US | disclosed |
| EP-1406620-A1 | VINYL PHENYL DERIVATIVES AS GLK ACTIVATORS | Astrazeneca AB (SE) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003000262-A1 | VINYL PHENYL DERIVATIVES AS GLK ACTIVATORS | ASTRAZENECA AB (SE) | 2003-01-03 | — | — | WO | disclosed |
| WO-2003000262-A1 | VINYL PHENYL DERIVATIVES AS GLK ACTIVATORS | ASTRAZENECA AB (SE) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054715-A1 | Vinyl phenyl derivatives as glk activators | GCK, GCKR, GK | GCK 1/4885PTGER1 428/4885RXRA 2155/4885 |
| US-20070093535-A1 | Vinyl phenyl derivatives as GLK activators | GCK, GCKR, GK | GCK 1/4885PTGER1 426/4885RXRA 2136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.