Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 2/20 | 0.64 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | RARA | P10276 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
| ▸ | RARG | P13631 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2642006 | 1.00 | GCK (0.64) | GCKMCL1ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL2642018 | 0.82 | GCK (0.70) | GCKALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL2642015 | 0.82 | GCK (0.70) | GCKALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL2398633 | 0.80 | GCK (0.55) | GCKALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL2398634 | 0.80 | GCK (0.55) | GCKALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL2642100 | 0.79 | GCK (1.00) | GCKHPGDRXRA | |
| SCHEMBL2642055 | 0.79 | GCK (1.00) | GCKHPGDRXRA | |
| SCHEMBL2642024 | 0.75 | GCK (0.80) | GCKHPGDRXRA | |
| SCHEMBL2642026 | 0.75 | GCK (0.80) | GCKHPGDRXRA | |
| SCHEMBL846747 | 0.69 | P4HA1 (0.53) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070093535-A1 | Vinyl phenyl derivatives as GLK activators | ASTRAZENECA AB | 2007-04-26 | — | — | US | disclosed |
| US-7199140-B2 | Vinyl phenyl derivatives as GLK activators | ASTRAZENECA AB (SE) | 2007-04-03 | — | — | US | disclosed |
| EP-1406620-B1 | VINYL PHENYL DERIVATIVES AS GLK ACTIVATORS | ASTRAZENECA AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| US-20050054715-A1 | Vinyl phenyl derivatives as glk activators | ASTRAZENECA AB (SE) | 2005-03-10 | — | — | US | disclosed |
| EP-1406620-A1 | VINYL PHENYL DERIVATIVES AS GLK ACTIVATORS | Astrazeneca AB (SE) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003000262-A1 | VINYL PHENYL DERIVATIVES AS GLK ACTIVATORS | ASTRAZENECA AB (SE) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054715-A1 | Vinyl phenyl derivatives as glk activators | GCK, GCKR, GK | GCK 1/4885MCL1 2280/4885ALDH1A1 1706/4885 |
| US-20070093535-A1 | Vinyl phenyl derivatives as GLK activators | GCK, GCKR, GK | GCK 1/4885MCL1 2399/4885ALDH1A1 1641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.