Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | FAAH | O00519 | 2/20 | 0.45 |
| ▸ | MGLL | Q99685 | 2/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | CRHBP | P24387 | 2/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL27994032 | 1.00 | ALDH1A1 (0.53) | ALDH1A1FAAHMGLLNCOA3KMT2A | |
| Biphenyl SCHEMBL27496289 | 0.97 | ALDH1A1 (0.50) | ALDH1A1FAAHMGLLNCOA3KMT2A | |
| Biphenyl SCHEMBL22123804 | 0.88 | ALDH1A1 (0.60) | ALDH1A1FAAHMGLLNCOA3KMT2A | |
| Biphenyl SCHEMBL1476553 | 0.88 | ALDH1A1 (0.60) | ALDH1A1FAAHMGLLNCOA3KMT2A | |
| Biphenyl SCHEMBL7773788 | 0.88 | ALDH1A1 (0.60) | ALDH1A1FAAHMGLLNCOA3KMT2A | |
| Tetrahydrofuran SCHEMBL28208415 | 0.86 | MMP3 (0.65) | FAAHMGLLNCOA3KMT2AMEN1 | |
| Biphenyl-4-Amine SCHEMBL28769252 | 0.86 | CYP3A4 (0.65) | ALDH1A1FAAHMGLLNCOA3KMT2A | |
| Tetrahydrofuran SCHEMBL28059145 | 0.86 | ALDH1A1 (0.65) | ALDH1A1FAAHMGLLNCOA3KMT2A | |
| Biphenyl SCHEMBL28279980 | 0.85 | ALDH1A1 (0.56) | ALDH1A1FAAHMGLLNCOA3KMT2A | |
| Biphenyl SCHEMBL28029327 | 0.85 | ALDH1A1 (0.56) | ALDH1A1FAAHMGLLNCOA3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501815-A1 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003095438-A9 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2004-12-23 | — | — | WO | disclosed |
| WO-2003095438-A1 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-20 | — | — | WO | disclosed |