SCHEMBL26425916

SCHEMBL26425916

NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1C(=O)CCc1cccc2ccccc12

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 1/20 0.41
PREP P48147 5/20 0.41
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
GRM2 Q14416 1/20 0.39
GRM3 Q14832 1/20 0.39
SLC18A2 Q05940 1/20 0.39
SIGMAR1 Q99720 1/20 0.39
KCNA5 P22460 2/20 0.38
SCN5A Q14524 2/20 0.38
EPHX1 P07099 1/20 0.38
P2RX7 Q99572 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26425956 0.79 DPP4 (0.48) MTNR1APREPMEN1KMT2ASIGMAR1
SCHEMBL26428548 0.77 DPP4 (0.52) PREPMEN1KMT2A
SCHEMBL26429246 0.72 DPP4 (0.48) SIGMAR1
SCHEMBL26429036 0.70 GRM2 (0.43) MTNR1APREPGRM2GRM3
SCHEMBL24158329 0.70 PREP (0.53) PREPMEN1KMT2A
SCHEMBL9774278 0.69 ACE (0.54) PREPMEN1KMT2A
SCHEMBL11958401 0.69 KMT2A (0.59) MEN1KMT2A
SCHEMBL961507 0.68 MTNR1A (0.63) MTNR1AMEN1KMT2AP2RX7
SCHEMBL9773813 0.68 ACE (0.55) PREPMEN1KMT2A
SCHEMBL15229937 0.67 KMT2A (0.56) MTNR1AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4170347-A1 GASTRIC INHIBITORY PEPTIDE RECEPTOR LIGANDS 3B Pharmaceuticals GmbH (DE) 2023-04-26 EP disclosed