Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26428976 | 1.00 | NPSR1 (0.47) | NPSR1ALDH1A1KMT2ATP53POLB | |
| SCHEMBL26092608 | 1.00 | NPSR1 (0.47) | NPSR1ALDH1A1KMT2ATP53POLB | |
| SCHEMBL31015904 | 1.00 | NPSR1 (0.47) | NPSR1ALDH1A1KMT2ATP53POLB | |
| SCHEMBL31015900 | 1.00 | NPSR1 (0.47) | NPSR1ALDH1A1KMT2ATP53POLB | |
| SCHEMBL30349607 | 1.00 | NPSR1 (0.47) | NPSR1ALDH1A1KMT2ATP53POLB | |
| SCHEMBL30728812 | 0.90 | PDE4B (0.54) | NPSR1ALDH1A1KMT2ATP53POLB | |
| SCHEMBL26093038 | 0.86 | FDFT1 (0.46) | ALDH1A1POLBSMN1; SMN2MAPTKDM4E | |
| SCHEMBL26092030 | 0.86 | FDFT1 (0.46) | ALDH1A1POLBSMN1; SMN2MAPTKDM4E | |
| SCHEMBL31386285 | 0.86 | PDE4B (0.53) | NPSR1ALDH1A1KMT2ATP53POLB | |
| SCHEMBL8040438 | 0.83 | NAMPT (0.54) | NPSR1ALDH1A1KMT2ATP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240425482-A1 | PYRROLIDINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2024-12-26 | — | — | US | disclosed |
| EP-4419516-A1 | PYRROLIDINE DERIVATIVES AS DDRS INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2024-08-28 | — | — | EP | disclosed |
| WO-2023066834-A1 | PYRROLIDINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2023-04-27 | — | — | WO | disclosed |
| WO-2023066834-A1 | PYRROLIDINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2023-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240425482-A1 | PYRROLIDINE DERIVATIVES AS DDRS INHIBITORS | DDR1, DDR2, DDRGK1 | NPSR1 1230/4885ALDH1A1 3779/4885KMT2A 3730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.