Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | TDO2 | P48775 | 6/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.49 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14631235 | 0.87 | MAPK1 (0.64) | MAPK1PIM3KDM4EGPR84ALDH1A1 | |
| SCHEMBL4238805 | 0.86 | TDO2 (0.49) | MAPK1TDO2KDM4EGPR84ALDH1A1 | |
| SCHEMBL30417250 | 0.83 | KDM4E (0.66) | TDO2KDM4EGPR84MEN1ALDH1A1 | |
| SCHEMBL2818109 | 0.83 | KDM4E (0.66) | TDO2KDM4EGPR84MEN1ALDH1A1 | |
| SCHEMBL2643312 | 0.83 | MAPK1 (0.62) | MAPK1PIM3KDM4EMEN1ALDH1A1 | |
| SCHEMBL14631607 | 0.83 | MAPK1 (0.62) | MAPK1PIM3GPR84MEN1ALDH1A1 | |
| SCHEMBL613310 | 0.83 | MAPK1 (0.62) | MAPK1PIM3GPR84MEN1ALDH1A1 | |
| SCHEMBL29644278 | 0.83 | MEN1 (0.65) | MAPK1PIM3MEN1ALDH1A1CYP1A2 | |
| SCHEMBL2133676 | 0.83 | MEN1 (0.65) | MAPK1PIM3MEN1ALDH1A1CYP1A2 | |
| SCHEMBL2642973 | 0.83 | MAPK1 (0.62) | MAPK1PIM3MEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083588-B1 | AROMATIC HETEROCYCLIC COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS | SUNSHINE LAKE PHARMA CO LTD (CN) | 2020-12-09 | — | — | EP | disclosed |
| US-9676715-B2 | Bis-indolic derivatives, a process for preparing the same and their uses as a drug | UNIVERSITE JOSEPH FOURIER (FR) | 2017-06-13 | — | — | US | disclosed |
| US-9663498-B2 | Aromatic heterocyclic compounds and their application in pharmaceuticals | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2017-05-30 | — | — | US | disclosed |
| US-20160251339-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-09-01 | — | — | US | disclosed |
| US-20140309272-A1 | BIS-INDOLIC DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG | UNIVERSITE JOSEPH FOURIER (FR) | 2014-10-16 | — | — | US | disclosed |
| EP-2548864-B1 | NOVEL BIS-INDOLIC DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG | UNIV JOSEPH FOURIER (FR) | 2014-02-19 | — | — | EP | disclosed |
| WO-2013014102-A1 | BIS-INDOLIC DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG | UNIVERSITE JOSEPH FOURIER (FR) | 2013-01-31 | — | — | WO | disclosed |
| EP-2548864-A1 | NOVEL BIS-INDOLIC DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG | Université Joseph Fourier (FR) | 2013-01-23 | — | — | EP | disclosed |
| EP-1549638-B1 | INDOLE-3-CARBOXAMIDES AS GLUCOKINASE (GK) ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2007-10-03 | — | — | EP | disclosed |
| EP-1549638-A1 | INDOLE-3-CARBOXAMIDES AS GLUCOKINASE (GK) ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-07-06 | — | — | EP | disclosed |
| US-6881844-B2 | Indole-3-carboxamides as glucokinase activators | HOFFMAN-LA ROCHE INC. (US) | 2005-04-19 | — | — | US | disclosed |
| WO-2004031179-A1 | INDOLE-3-CARBOXAMIDES AS GLUCOKINASE (GK) ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-15 | — | — | WO | disclosed |
| US-20040067939-A1 | Indole-3-carboxamides as glucokinase activators | CORBETT WENDY LEA (US) | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067939-A1 | Indole-3-carboxamides as glucokinase activators | GCKR, GPR119, GCK | MAPK1 1197/4885TDO2 208/4885PIM3 734/4885 |
| US-20160251339-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS | MAPT, APP, PSEN1 | MAPK1 2363/4885TDO2 136/4885PIM3 3243/4885 |
| US-20140309272-A1 | BIS-INDOLIC DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG | IDO1, ITPA, IDO2 | MAPK1 3685/4885TDO2 30/4885PIM3 973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.