Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 6/20 | 0.51 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.51 |
| ▸ | GIPR | P48546 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GSR | P00390 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAT2A | P31153 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2642765 | 0.82 | PLA2G10 (0.52) | GCGRPLA2G10GIPRKCNH2HTT | |
| SCHEMBL2643230 | 0.81 | GCGR (0.55) | GCGRPLA2G10GIPRKCNH2HTT | |
| SCHEMBL721418 | 0.81 | GCGR (0.57) | GCGRPLA2G10GIPRKCNH2MAT2A | |
| SCHEMBL2643458 | 0.78 | GCGR (0.54) | GCGRPLA2G10GIPRKCNH2MAT2A | |
| SCHEMBL2643861 | 0.78 | GCGR (0.56) | GCGRPLA2G10GIPRKCNH2HTT | |
| SCHEMBL9987241 | 0.78 | PLA2G10 (0.47) | GCGRPLA2G10ALDH1A1KDM4EHTT | |
| SCHEMBL2643993 | 0.75 | GCGR (0.52) | GCGRPLA2G10GIPRKCNH2MAT2A | |
| SCHEMBL2643376 | 0.74 | GCGR (0.43) | GCGRPLA2G10KDM4EPOLBMAPT | |
| SCHEMBL1253237 | 0.73 | RXFP1 (0.56) | NPSR1ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL12930106 | 0.73 | NOD2 (0.58) | ALDH1A1PPARGPOLBMAPTNOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598398-B2 | Acyl indoles, compositions containing such compounds and methods of use | MERCK & CO., INC. (US) | 2009-10-06 | — | — | US | disclosed |
| US-20070088071-A1 | Acyl indoles, compositions containing such compounds and methods of use | MERCK SHARP & DOHME LLC | 2007-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070088071-A1 | Acyl indoles, compositions containing such compounds and methods of use | GPR119, IAPP, GLP1R | GCGR 6/4885PLA2G10 909/4885GIPR 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.