Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NPY2R | P49146 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2643300 | 0.81 | HPGD (0.47) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL2643440 | 0.79 | ALDH1A1 (0.57) | ALDH1A1HPGDNPSR1MEN1KMT2A | |
| SCHEMBL2642822 | 0.70 | GCGR (0.47) | ALDH1A1HPGDNPSR1POLBKDM4E | |
| SCHEMBL11376733 | 0.69 | ALDH1A1 (0.77) | ALDH1A1HPGDNPSR1POLBKDM4E | |
| SCHEMBL2647695 | 0.67 | HPGD (0.47) | ALDH1A1HPGDPOLBKDM4EMEN1 | |
| SCHEMBL3803060 | 0.66 | ALDH1A1 (0.70) | ALDH1A1HPGDNPSR1KDM4ESMN1; SMN2 | |
| SCHEMBL8289336 | 0.66 | ALDH1A1 (0.76) | ALDH1A1HPGDNPSR1POLBKDM4E | |
| SCHEMBL5079928 | 0.66 | NPY2R (1.00) | ALDH1A1NPSR1POLBKDM4EMEN1 | |
| SCHEMBL13576561 | 0.66 | ALDH1A1 (0.65) | ALDH1A1HPGDNPSR1POLBKDM4E | |
| SCHEMBL8913629 | 0.65 | ALDH1A1 (0.57) | ALDH1A1HPGDNPSR1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196106-B2 | Cyanothiophene derivatives, compositions containing such compounds and methods of use | MERCK & CO., INC (US) | 2007-03-27 | — | — | US | disclosed |
| US-20040097552-A1 | Cyanothiophene derivatives, compositions containing such compounds and methods of use | MERCK SHARP & DOHME CORP. | 2004-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097552-A1 | Cyanothiophene derivatives, compositions containing such compounds and methods of use | GLP1R, GPR119, GCGR | ALDH1A1 2652/4885HPGD 1674/4885NPSR1 292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.