Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | RBP4 | P02753 | 5/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 6/20 | 0.33 |
| ▸ | SSTR1 | P30872 | 3/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.31 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | WEE1 | P30291 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21776744 | 0.90 | TLR7 (0.34) | TLR7TLR9TLR8RBP4SSTR4 | |
| SCHEMBL21776764 | 0.89 | TLR7 (0.34) | TLR7TLR9TLR8RBP4SSTR4 | |
| SCHEMBL21795520 | 0.89 | TLR7 (0.35) | TLR7TLR9TLR8RBP4SSTR4 | |
| SCHEMBL21795288 | 0.89 | RBP4 (0.33) | TLR7TLR9TLR8RBP4SSTR4 | |
| SCHEMBL21795284 | 0.88 | HTR3A (0.37) | TLR7TLR9TLR8SSTR4SSTR1 | |
| SCHEMBL21795286 | 0.88 | TLR7 (0.32) | TLR7TLR9TLR8RBP4SSTR4 | |
| SCHEMBL21795524 | 0.86 | GAA (0.39) | TLR7TLR9TLR8SSTR4SSTR1 | |
| SCHEMBL21776658 | 0.85 | SSTR4 (0.33) | TLR7TLR9TLR8RBP4SSTR4 | |
| SCHEMBL21795527 | 0.85 | TLR7 (0.37) | TLR7TLR9TLR8RBP4SSTR4 | |
| SCHEMBL21795318 | 0.85 | TLR7 (0.37) | TLR7TLR9TLR8RBP4SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3844159-B1 | NOVEL PYRROLIDINYL AMIDE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN LA ROCHE (CH) | 2023-05-03 | — | — | EP | disclosed |