Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.53 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | ALDH1A2 | O94788 | 3/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31329494 | 0.87 | MAP4K1 (0.51) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL31329495 | 0.87 | MAP4K1 (0.51) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL21646064 | 0.87 | MAP4K1 (0.51) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL23674722 | 0.84 | CRBN (0.49) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL30100726 | 0.84 | CRBN (0.49) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL26088019 | 0.84 | ULK1 (0.53) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL30100712 | 0.84 | ULK1 (0.53) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL31341310 | 0.84 | MAP4K1 (0.59) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL21686954 | 0.84 | MAP4K1 (0.59) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL30100710 | 0.83 | CRBN (0.48) | MAP4K1CRBNHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230128402-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | THE TRUSTEES OF PRINCETON UNIVERSITY | 2023-04-27 | — | — | US | disclosed |
| US-20230128402-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | THE TRUSTEES OF PRINCETON UNIVERSITY | 2023-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230128402-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | PAH, ALDH2, IDH2 | MAP4K1 1207/4885CRBN 3317/4885HDAC3 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.