Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 3/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26451317 | 1.00 | PDE4B (0.44) | PDE4BPIK3CDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL26451281 | 1.00 | PDE4B (0.44) | PDE4BPIK3CDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL26452643 | 0.85 | CHRM5 (0.36) | PIK3CDCYP2C19GRIN2BCHRM4CYP2C9 | |
| SCHEMBL26452546 | 0.85 | CHRM5 (0.36) | PIK3CDCYP2C19GRIN2BCHRM4CYP2C9 | |
| SCHEMBL26452466 | 0.85 | CHRM5 (0.36) | PIK3CDCYP2C19GRIN2BCHRM4CYP2C9 | |
| SCHEMBL22519703 | 0.84 | PDE4B (0.54) | PDE4BPIK3CDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL18740319 | 0.82 | SMN1; SMN2 (0.49) | PDE4BPIK3CDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL14778858 | 0.81 | SMN1; SMN2 (0.56) | PDE4BPIK3CDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL22292218 | 0.81 | SMN1; SMN2 (0.56) | PDE4BPIK3CDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL18842331 | 0.81 | SMN1; SMN2 (0.56) | PDE4BPIK3CDSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230139156-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF UPADACITINIB | CURIA SPAIN, S.A.U. (ES) | 2023-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230139156-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF UPADACITINIB | CDK19, CDK11B, CDK9 | PDE4B 1354/4885PIK3CD 158/4885SMN1; SMN2 2419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.