SCHEMBL26460940

SCHEMBL26460940

COCCCOC(=O)N1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 12/20 0.67
LMNA P02545 6/20 0.66
MAPT P10636 6/20 0.66
SMN1; SMN2 Q16637 5/20 0.66
CYP3A4 P08684 4/20 0.66
MAPK1 P28482 4/20 0.66
TP53 P04637 3/20 0.66
RAD52 P43351 3/20 0.66
DRD2 P14416 3/20 0.66
DRD1 P21728 3/20 0.66
HRH1 P35367 3/20 0.66
DRD3 P35462 3/20 0.66
ALDH1A1 P00352 2/20 0.66
CYP1A2 P05177 2/20 0.66
ABCB1 P08183 2/20 0.66
HTR1A P08908 2/20 0.66
ADRA2A P08913 2/20 0.66
ADORA3 P0DMS8 2/20 0.66
CYP2D6 P10635 2/20 0.66
CHRM1 P11229 2/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19067486 0.96 FPR2 (0.68) FPR2LMNAMAPTSMN1; SMN2CYP3A4
SCHEMBL19067433 0.93 FPR2 (0.70) FPR2LMNAMAPTSMN1; SMN2CYP3A4
SCHEMBL19067435 0.93 FPR2 (0.70) FPR2LMNAMAPTSMN1; SMN2CYP3A4
SCHEMBL19067434 0.93 FPR2 (0.70) FPR2LMNAMAPTSMN1; SMN2CYP3A4
SCHEMBL19067436 0.93 FPR2 (0.70) FPR2LMNAMAPTSMN1; SMN2CYP3A4
SCHEMBL19750654 0.87 DRD2 (0.64) FPR2LMNAMAPTSMN1; SMN2CYP3A4
SCHEMBL30534415 0.86 FPR2 (0.71) FPR2LMNAMAPTSMN1; SMN2CYP3A4
SCHEMBL21445213 0.86 FPR2 (0.71) FPR2LMNAMAPTSMN1; SMN2CYP3A4
SCHEMBL19068438 0.86 FPR2 (0.74) FPR2LMNAMAPTSMN1; SMN2CYP3A4
SCHEMBL19750688 0.85 FPR2 (0.70) FPR2LMNAMAPTSMN1; SMN2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3525795-B1 PHENOTHIAZINE DERIVATIVES AND METHODS OF USE THEREOF ENROCK PHARMACEUTICAL TECH HEBEI LIMITED (CN) 2023-04-26 EP disclosed