Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.51 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.51 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.51 |
| ▸ | KIF11 | P52732 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.51 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2646131 | 0.90 | ALDH1A1 (0.56) | MEN1KMT2AHSP90AA1ALDH1A1TDP1 | |
| SCHEMBL11590982 | 0.85 | ALDH1A1 (0.56) | MEN1KMT2AALDH1A1TDP1CYP3A4 | |
| SCHEMBL10527427 | 0.85 | ALDH1A1 (0.53) | MEN1KMT2AALDH1A1TDP1CYP3A4 | |
| SCHEMBL10799433 | 0.84 | MEN1 (0.55) | MEN1KMT2AHSP90AA1ALDH1A1TDP1 | |
| SCHEMBL13811262 | 0.82 | MAPK1 (0.75) | MEN1KMT2AALDH1A1TDP1CYP3A4 | |
| SCHEMBL10802521 | 0.81 | MAPK1 (0.58) | MEN1KMT2AALDH1A1TDP1CYP3A4 | |
| SCHEMBL10527474 | 0.80 | MAPT (0.65) | MEN1KMT2AALDH1A1CYP3A4HPGD | |
| SCHEMBL10796892 | 0.80 | KIF11 (0.58) | MEN1KMT2AALDH1A1HPGDKIF11 | |
| SCHEMBL11156657 | 0.80 | KMT2A (0.79) | MEN1KMT2AHSP90AA1ALDH1A1TDP1 | |
| SCHEMBL11149199 | 0.80 | MAPT (0.55) | MEN1KMT2AHSP90AA1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0616807-B1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH AS (DK) | 1998-07-08 | — | — | EP | disclosed |
| US-5554632-A | CENTRAL NERVOUS SYSTEM | NEUROSEARCH A/S (DK) | 1996-09-10 | — | — | US | disclosed |
| US-5554630-A | TREATING ANXIETY, CONVULSIONS AND SLEEP DISORDERS IN LIVING ANIMALS BY MODULATION OF THE BENZODIAZEPINE RECEPTOR OF THE CENTRAL NERVOUS SYSTEM WITH 1-/3-HETEROCYCLYLPHENYL/-BENZIMIDAZOLES | NEUROSEARCH A/S (DK) | 1996-09-10 | — | — | US | disclosed |
| EP-0616807-A1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH A/S (DK) | 1994-09-28 | — | — | EP | disclosed |
| US-4152460-A | FUNGICIDES | ELI LILLY AND COMPANY (US) | 1979-05-01 | — | — | US | disclosed |
| US-4117167-A | INSECTICIDES, ACARICIDES | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1978-09-26 | — | — | US | disclosed |