Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 17/20 | 0.54 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.48 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.39 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26463608 | 0.94 | CACNA1H (0.56) | CACNA1HCACNA1ICACNA1GCYP2D6KCNH2 | |
| SCHEMBL26465838 | 0.93 | CACNA1H (0.55) | CACNA1HCACNA1ICACNA1GCYP2D6KCNH2 | |
| SCHEMBL26465689 | 0.89 | CACNA1H (0.54) | CACNA1HCACNA1ICACNA1G | |
| SCHEMBL26466387 | 0.86 | CACNA1H (0.49) | CACNA1HCACNA1ICACNA1GCYP2D6KCNH2 | |
| SCHEMBL26466390 | 0.86 | CACNA1H (0.49) | CACNA1HCACNA1ICACNA1GCYP2D6KCNH2 | |
| SCHEMBL26466398 | 0.86 | CACNA1H (0.49) | CACNA1HCACNA1ICACNA1GCYP2D6KCNH2 | |
| SCHEMBL26465573 | 0.86 | CACNA1H (0.72) | CACNA1H | |
| SCHEMBL26465833 | 0.86 | CACNA1H (0.56) | CACNA1HCACNA1ICYP2D6KCNH2CXCR6 | |
| SCHEMBL26464640 | 0.86 | CACNA1H (0.68) | CACNA1HCACNA1ICACNA1G | |
| SCHEMBL26498845 | 0.85 | CACNA1H (0.64) | CACNA1HCACNA1ICACNA1GCYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |