Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 16/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.47 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26464490 | 0.93 | CACNA1H (0.54) | CACNA1HCYP2D6KCNH2CACNA1ICXCR6 | |
| SCHEMBL26465833 | 0.91 | CACNA1H (0.56) | CACNA1HCYP2D6KCNH2CACNA1ICXCR6 | |
| SCHEMBL26464500 | 0.89 | CACNA1H (0.70) | CACNA1HCXCR6DRD4 | |
| SCHEMBL26463608 | 0.86 | CACNA1H (0.56) | CACNA1HCYP2D6KCNH2CACNA1ICACNA1G | |
| SCHEMBL26464783 | 0.85 | CACNA1H (0.46) | CACNA1HCYP2D6KCNH2CACNA1ICACNA1G | |
| SCHEMBL26465699 | 0.85 | HPGD (0.55) | CACNA1HCYP2D6ALDH1A1 | |
| SCHEMBL26466613 | 0.85 | CACNA1H (0.52) | CACNA1HCYP2D6KCNH2CACNA1ICXCR6 | |
| SCHEMBL26498770 | 0.83 | CACNA1H (0.74) | CACNA1HCYP2D6KCNH2CACNA1IALDH1A1 | |
| SCHEMBL26465689 | 0.83 | CACNA1H (0.54) | CACNA1HCACNA1IALDH1A1CACNA1GDRD4 | |
| SCHEMBL26106607 | 0.80 | CACNA1H (0.60) | CACNA1HCYP2D6KCNH2CACNA1IALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |