Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24015591 | 1.00 | GCK (0.45) | GCKCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL24015604 | 1.00 | GCK (0.45) | GCKCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL25587652 | 0.85 | RIPK1 (0.42) | CYP3A4CYP2C19CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL25587646 | 0.85 | RIPK1 (0.42) | CYP3A4CYP2C19CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL25587653 | 0.85 | RIPK1 (0.42) | CYP3A4CYP2C19CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL7491275 | 0.82 | GAA (0.61) | CYP3A4CYP2C19CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL24015592 | 0.78 | CHRNB2 (0.58) | CYP3A4CYP2C19TRPA1LMNAPSEN1 | |
| SCHEMBL24015590 | 0.78 | CHRNB2 (0.58) | CYP3A4CYP2C19TRPA1LMNAPSEN1 | |
| SCHEMBL24015576 | 0.78 | CHRNB2 (0.58) | CYP3A4CYP2C19TRPA1LMNAPSEN1 | |
| SCHEMBL15240483 | 0.77 | SMN1; SMN2 (0.44) | GCKCYP3A4CYP2C19SMN1; SMN2TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023072974-A1 | TRICYCLIC HETEROCYCLES | MERCK PATENT GMBH (DE) | 2023-05-04 | — | — | WO | disclosed |