Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 10/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26465828 | 0.90 | ALDH1A1 (0.48) | ALDH1A1KDM4ECACNA1HLMNATHRB | |
| SCHEMBL26465831 | 0.78 | ALDH1A1 (0.50) | ALDH1A1KDM4ECACNA1HPSMB5 | |
| SCHEMBL26466619 | 0.74 | ALDH1A1 (0.43) | ALDH1A1KDM4ECACNA1HLMNATHRB | |
| SCHEMBL26465830 | 0.74 | CACNA1H (0.73) | ALDH1A1KDM4ECACNA1HPSMB5KMT2A | |
| SCHEMBL26465978 | 0.73 | KDM4E (0.45) | ALDH1A1KDM4ECACNA1HPSMB5MEN1 | |
| SCHEMBL26465836 | 0.72 | CACNA1H (0.56) | ALDH1A1KDM4ECACNA1HPSMB5EPHX1 | |
| SCHEMBL26465834 | 0.70 | MEN1 (0.48) | ALDH1A1KDM4ECACNA1HPSMB5MEN1 | |
| SCHEMBL26463801 | 0.68 | CACNA1H (0.71) | ALDH1A1KDM4ECACNA1HKMT2A | |
| SCHEMBL26466782 | 0.68 | KDM4E (0.42) | ALDH1A1KDM4ECACNA1HPSMB5MAPT | |
| SCHEMBL4217027 | 0.68 | ALDH1A1 (0.60) | ALDH1A1KDM4ECACNA1HPSMB5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |