Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 2/20 | 0.36 |
| ▸ | UGCG | Q16739 | 2/20 | 0.36 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26465828 | 0.83 | ALDH1A1 (0.48) | ALDH1A1KDM4ECACNA1HPSMB5LMNA | |
| SCHEMBL26466782 | 0.80 | KDM4E (0.42) | ALDH1A1KDM4ECACNA1HPSMB5GBA1 | |
| SCHEMBL26465843 | 0.74 | ALDH1A1 (0.49) | ALDH1A1KDM4ECACNA1HPSMB5LMNA | |
| SCHEMBL26466599 | 0.74 | CACNA1H (0.70) | ALDH1A1KDM4ECACNA1HEPHX2KMT2A | |
| SCHEMBL26466781 | 0.74 | KDM4E (0.45) | ALDH1A1KDM4ECACNA1HPSMB5GBA1 | |
| SCHEMBL26466783 | 0.72 | ALDH1A1 (0.43) | ALDH1A1KDM4ECACNA1HPSMB5GBA1 | |
| SCHEMBL26466910 | 0.72 | KDM4E (0.46) | ALDH1A1KDM4ECACNA1HPSMB5EPHX2 | |
| SCHEMBL26466911 | 0.71 | CACNA1H (0.46) | ALDH1A1KDM4ECACNA1HPSMB5GBA1 | |
| SCHEMBL26466771 | 0.69 | MEN1 (0.46) | ALDH1A1KDM4ECACNA1HGBA1UGCG | |
| SCHEMBL26466205 | 0.68 | CACNA1H (0.68) | ALDH1A1KDM4ECACNA1HEPHX2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |