Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 9/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26466781 | 0.81 | KDM4E (0.45) | KDM4EALDH1A1CACNA1HEPHX1EPHX2 | |
| SCHEMBL26466599 | 0.77 | CACNA1H (0.70) | KDM4EALDH1A1CACNA1HEPHX2 | |
| SCHEMBL26466911 | 0.74 | CACNA1H (0.46) | KDM4EALDH1A1CACNA1HEPHX2ATM | |
| SCHEMBL26466619 | 0.72 | ALDH1A1 (0.43) | KDM4EALDH1A1CACNA1HEPHX2ATM | |
| SCHEMBL26466772 | 0.71 | KDM4E (0.40) | KDM4EALDH1A1CACNA1HEPHX1EPHX2 | |
| SCHEMBL26466205 | 0.71 | CACNA1H (0.68) | KDM4EALDH1A1CACNA1HEPHX1EPHX2 | |
| SCHEMBL26466782 | 0.70 | KDM4E (0.42) | KDM4EALDH1A1CACNA1HEPHX1PSMB5 | |
| SCHEMBL26466783 | 0.70 | ALDH1A1 (0.43) | KDM4EALDH1A1CACNA1HEPHX2PSMB5 | |
| SCHEMBL26466764 | 0.69 | CACNA1H (0.55) | KDM4EALDH1A1CACNA1H | |
| SCHEMBL26466771 | 0.69 | MEN1 (0.46) | KDM4EALDH1A1CACNA1HEPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |