Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 9/20 | 0.41 |
| ▸ | MGAM | O43451 | 7/20 | 0.41 |
| ▸ | SI | P14410 | 7/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 7/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30130801 | 0.85 | ALDH1A1 (0.46) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL23727277 | 0.85 | ALDH1A1 (0.46) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL23727594 | 0.76 | MGAM (0.41) | GAAMGAMSIMGAM2RXFP1 | |
| SCHEMBL23727596 | 0.76 | MGAM (0.41) | GAAMGAMSIMGAM2RXFP1 | |
| SCHEMBL23727063 | 0.73 | GAA (0.41) | GAAMGAMSIMGAM2RXFP1 | |
| SCHEMBL23727066 | 0.73 | GAA (0.41) | GAAMGAMSIMGAM2RXFP1 | |
| SCHEMBL23727068 | 0.73 | ALDH1A1 (0.45) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL23727067 | 0.73 | ALDH1A1 (0.45) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL25001956 | 0.73 | ALDH1A1 (0.43) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL25001957 | 0.71 | GAA (0.39) | GAAMGAMSIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230137893-A1 | PYRROLO[2,3-b]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | THE ROCKEFELLER UNIVERSITY (US) | 2023-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230137893-A1 | PYRROLO[2,3-b]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | LATS2, LATS1, YAP1 | GAA 4035/4885MGAM 4731/4885SI 4172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.