Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000618 | 0.94 | SLC6A3 (0.47) | SLC6A3TAS1R3TAS1R1SLC6A2SLC6A4 | |
| SCHEMBL10650293 | 0.87 | SLC6A3 (0.48) | SLC6A3SLC6A2SLC6A4ALDH1A1LMNA | |
| SCHEMBL9734725 | 0.85 | SLC6A3 (0.46) | SLC6A3SLC6A2SLC6A4ALDH1A1LMNA | |
| SCHEMBL10651696 | 0.85 | SLC6A3 (0.46) | SLC6A3SLC6A2SLC6A4ALDH1A1LMNA | |
| SCHEMBL631558 | 0.84 | SLC6A3 (0.50) | SLC6A3SLC6A2SLC6A4ALDH1A1LMNA | |
| SCHEMBL10651698 | 0.83 | SLC6A3 (0.49) | SLC6A3SLC6A2SLC6A4ALDH1A1LMNA | |
| SCHEMBL10650297 | 0.83 | SLC6A3 (0.49) | SLC6A3SLC6A2SLC6A4ALDH1A1LMNA | |
| SCHEMBL632673 | 0.82 | SLC6A3 (0.48) | SLC6A3SLC6A2SLC6A4ALDH1A1LMNA | |
| SCHEMBL1460292 | 0.81 | SMN1; SMN2 (0.47) | SLC6A3SLC6A2SLC6A4ALDH1A1LMNA | |
| SCHEMBL25304057 | 0.80 | ALDH1A1 (0.49) | TAS1R3TAS1R1ALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169312-B1 | GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2004-10-06 | — | — | EP | disclosed |
| US-6528543-B1 | Glucokinase activating for treating type II diabetes; acylurea compound, phenylacetyl-substituted; 1-(2-(3-chloro-phenyl)-3cyclopentyl-propionyl)-3-methyl-urea | HOFFMAN-LA ROCHE INC. | 2003-03-04 | — | — | US | disclosed |
| EP-1169312-A2 | GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000058293-A2 | GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-10-05 | — | — | WO | disclosed |