Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 7/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.36 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26968221 | 0.84 | CHEK1 (0.46) | CHEK1EGLN1NAMPTARSLC40A1 | |
| SCHEMBL14873531 | 0.82 | CHEK1 (0.39) | CHEK1EGLN1NAMPTARSLC40A1 | |
| SCHEMBL26968171 | 0.81 | CHEK1 (0.42) | CHEK1EGLN1NAMPTAR | |
| SCHEMBL6348729 | 0.80 | LOXL2 (0.52) | CHEK1EGLN1NAMPTAR | |
| SCHEMBL7993913 | 0.80 | CHEK1 (0.40) | CHEK1EGLN1NAMPTSLC40A1SLC8A1 | |
| SCHEMBL7992498 | 0.80 | CHEK1 (0.42) | CHEK1EGLN1NAMPTSLC40A1 | |
| SCHEMBL453185 | 0.80 | CHEK1 (0.44) | CHEK1EGLN1NAMPTARGRM2 | |
| SCHEMBL6348726 | 0.79 | CHEK1 (0.40) | CHEK1EGLN1NAMPTARSLC40A1 | |
| SCHEMBL7999494 | 0.78 | CHEK1 (0.38) | CHEK1EGLN1NAMPTSLC40A1SLC8A1 | |
| SCHEMBL9840551 | 0.78 | MC4R (0.44) | CHEK1EGLN1NAMPTSLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023072257-A1 | PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITORS AND USES THEREOF | INSILICO MEDICINE IP LIMITED (CN) | 2023-05-04 | — | — | WO | disclosed |
| WO-2023072246-A1 | PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITORS AND USES THEREOF | INSILICO MEDICINE IP LIMITED (CN) | 2023-05-04 | — | — | WO | disclosed |