Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.50 |
| ▸ | F12 | P00748 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | NOS3 | P29474 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | NOS2 | P35228 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30050701 | 0.98 | PLAU (0.48) | PLAUCYP2A6F12NCF1NOS3 | |
| Hydrochloric Acid SCHEMBL10435179 | 0.98 | PLAU (0.48) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL8570368 | 0.84 | ACHE (0.49) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL3248709 | 0.79 | PLAU (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL3112515 | 0.79 | PLAU (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL242954 | 0.79 | PLAU (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL3294474 | 0.79 | PLAU (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL243297 | 0.79 | PLAU (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL3105082 | 0.79 | PLAU (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL291937 | 0.79 | PLAU (0.50) | PLAUCYP2A6F12NCF1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-63179871-A | — | — | None | — | — | JP | disclosed |
| EP-3697747-B1 | PROCESS FOR THE CHLORINATION AT THE ALPHA-H POSITION OF ALKYLARENES VARIOUSLY SUBSTITUTED ON THE AROMATIC RING | UNIV DEGLI STUDI CAGLIARI (IT) | 2022-06-08 | — | — | EP | disclosed |
| US-11168037-B2 | Process for the halogenation at the alpha-h position of alkylarenes variously substituted on the aromatic ring | UNIVERSITÀ DEGLI STUDI DI SASSARI (IT) | 2021-11-09 | — | — | US | disclosed |
| US-20210188733-A1 | PROCESS FOR THE HALOGENATION AT THE ALPHA-H POSITION OF ALKYLARENES VARIOUSLY SUBSTITUTED ON THE AROMATIC RING | UNIVERSITÀ DEGLI STUDI DI CAGLIARI (IT) | 2021-06-24 | — | — | US | disclosed |
| WO-2019077520-A1 | PROCESS FOR THE HALOGENATION AT THE ALPHA-H POSITION OF ALKYLARENES VARIOUSLY SUBSTITUTED ON THE AROMATIC RING | UNIVERSITA' DEGLI STUDI DI CAGLIARI (IT) | 2019-04-25 | — | — | WO | disclosed |
| US-7732540-B2 | Process for producing olefin copolymerization catalyst and process for producing olefin copolymer | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-06-08 | — | — | US | disclosed |
| EP-1998775-B1 | BIS1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR USES AS PHARMACEUTICALS | UNIV LIEGE (BE) | 2010-05-19 | — | — | EP | disclosed |
| CN-101490001-A | Substituted phenylacetic acids as DP-2 antagonists | ICOS CORP (US) | 2009-07-22 | — | — | CN | disclosed |
| US-20090093517-A1 | BIS1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR USES AS PHARMACEUTICALS | UNIVERSITE DE LIEGE (BE) | 2009-04-09 | — | — | US | disclosed |
| US-20090018012-A1 | Process for Producing Olefin Copolymerization Catalyst and Process for Producing Olefin Copolymer | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-01-15 | — | — | US | disclosed |
| US-6255305-B1 | PSYCHOLOGICAL DISORDERS | MERCK SHARP & DOHME LIMITED (GB) | 2001-07-03 | — | — | US | disclosed |
| EP-0915875-A2 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 1999-05-19 | — | — | EP | disclosed |
| US-5763437-A | Benzodiazepine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-09 | — | — | US | disclosed |
| WO-1998004559-A2 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1998-02-05 | — | — | WO | disclosed |
| EP-0804425-A2 | BENZODIAZEPINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996004254-A2 | BENZODIAZEPINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-15 | — | — | WO | disclosed |
| JP-S63179871-A | SUBSTITUTED ISOQUINOLINE DERIVATIVE AND ANTIULCER AGENT | SHIONOGI & CO LTD | 1988-07-23 | — | — | JP | disclosed |
| US-RE32519-E | Sulfur-containing isoquinoline derivatives, process for the preparation thereof and pharmaceutical compositions containing them | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA (HU) | 1987-10-13 | — | — | US | disclosed |
| US-4425349-A | DIURETICS, ANTIASTHMA, HYPOTENSIVE, ANTIINFLAMMATORY | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1984-01-10 | — | — | US | disclosed |
| US-4373104-A | DIURETICS; ANTIHISTAMINES; ANTINFLAMMATORY AND HYPOTENSIVE AGENTS | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA (HU) | 1983-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093517-A1 | BIS1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR USES AS PHARMACEUTICALS | KCNQ2, KCNQ1, KCNQ3 | PLAU 3845/4885CYP2A6 654/4885F12 4072/4885 |
| US-11168037-B2 | Process for the halogenation at the alpha-h position of alkylarenes variously substituted on the aromatic ring | AHR, DBH, DOHH | PLAU 4598/4885CYP2A6 306/4885F12 2892/4885 |
| US-20210188733-A1 | PROCESS FOR THE HALOGENATION AT THE ALPHA-H POSITION OF ALKYLARENES VARIOUSLY SUBSTITUTED ON THE AROMATIC RING | AHR, DBH, DOHH | PLAU 4598/4885CYP2A6 306/4885F12 2892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.