Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.47 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.44 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2647434 | 1.00 | TAS1R3 (0.47) | TAS1R3TAS1R2KMT2ASLC6A3SSTR3 | |
| SCHEMBL2646441 | 0.83 | TSHR (0.47) | TAS1R3TAS1R2KMT2AHPGDSIGMAR1 | |
| SCHEMBL2646437 | 0.83 | TSHR (0.47) | TAS1R3TAS1R2KMT2AHPGDSIGMAR1 | |
| SCHEMBL2645735 | 0.82 | GCK (0.42) | TAS1R3TAS1R2KMT2ATAS1R1 | |
| SCHEMBL2651148 | 0.82 | GCK (0.35) | TAS1R3TAS1R2KMT2ASLC6A3SSTR3 | |
| SCHEMBL2645730 | 0.82 | GCK (0.42) | TAS1R3TAS1R2KMT2ATAS1R1 | |
| SCHEMBL2650347 | 0.81 | GCK (0.34) | TAS1R3TAS1R2KMT2ASLC6A3SSTR3 | |
| SCHEMBL2649681 | 0.81 | GCK (0.34) | TAS1R3TAS1R2KMT2ASLC6A3SSTR3 | |
| SCHEMBL2646968 | 0.80 | TAS1R3 (0.46) | TAS1R3TAS1R2KMT2ASLC6A3SSTR3 | |
| SCHEMBL2646970 | 0.80 | TAS1R3 (0.46) | TAS1R3TAS1R2KMT2ASLC6A3SSTR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242397-B1 | TRANS OLEFINIC GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | EP | disclosed |
| EP-1242397-A1 | TRANS OLEFINIC GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6353111-B1 | WHICH INCREASE INSULIN SECRETION IN THE TREATMENT OF TYPE II DIABETES; 2,3-DI-SUBSTITUTED TRANS OLEFINIC N-HETEROAROMATIC OR URIDO PROPIONAMIDES: THE SUBSTITUTION AT THE 2-POSITION BEING A SUBSTITUTED PHENYL GROUP AND AT THE 3-POSITION A | HOFFMANN-LA ROCHE INC. | 2002-03-05 | — | — | US | disclosed |
| WO-2001044216-A1 | TRANS OLEFINIC GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-21 | — | — | WO | disclosed |