Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 4/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 6/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 3/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.32 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2650347 | 0.99 | GCK (0.34) | GCKTAS1R3TAS1R1TAS1R2PDE4A | |
| SCHEMBL2649681 | 0.99 | GCK (0.34) | GCKTAS1R3TAS1R1TAS1R2PDE4A | |
| SCHEMBL2650928 | 0.88 | TAS1R3 (0.32) | TAS1R3TAS1R1TAS1R2PDE4APDE4B | |
| SCHEMBL2650025 | 0.88 | GCK (0.33) | GCKTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL2650318 | 0.87 | GCK (0.32) | GCKTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL2650469 | 0.87 | GCK (0.32) | GCKTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL2649853 | 0.86 | GCK (0.32) | GCKTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL2649950 | 0.85 | TAS1R3 (0.34) | TAS1R3TAS1R1TAS1R2PDE4D | |
| SCHEMBL2650789 | 0.85 | GCK (0.36) | GCKKMT2A | |
| SCHEMBL2649604 | 0.83 | GCK (0.38) | GCKKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311504-A1 | TETRAZOLYL-PHENYL ACETAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014312-A1 | TETRAZOLYL-PHENYL ACETAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | disclosed |