SCHEMBL2647554

SCHEMBL2647554

c1ccc(-c2cccc(-n3cnc4cc(-n5cccc5)ccc43)c2)nc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.46
MAPT P10636 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
PPP1CA P62136 1/20 0.46
KMT2A Q03164 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
HTR1A P08908 1/20 0.44
HTR7 P34969 1/20 0.44
GRM5 P41594 1/20 0.44
FGFR1 P11362 10/20 0.43
KDM4E B2RXH2 1/20 0.41
NPC1 O15118 1/20 0.41
ALDH1A1 P00352 1/20 0.41
GAA P10253 1/20 0.41
RAB9A P51151 1/20 0.41
GFER P55789 1/20 0.41
GABRA1 P14867 1/20 0.41
GABRG2 P18507 1/20 0.41
GABRB3 P28472 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7831038 0.84 CYP1A2 (0.46) CYP1A2MAPTCYP2C9CYP2C19PPP1CA
SCHEMBL8462814 0.81 FGFR1 (0.41) FGFR1ALDH1A1GABRA1GABRG2GABRB3
SCHEMBL2651927 0.81 PRKCI (0.47) CYP1A2MAPTCYP2C9CYP2C19PPP1CA
SCHEMBL2646874 0.81 GABRA1 (0.57) GRM5FGFR1GABRA1GABRG2GABRB3
SCHEMBL2650727 0.79 FGFR1 (0.68) GRM5FGFR1NPC1ALDH1A1RAB9A
SCHEMBL2647245 0.79 GABRA1 (0.45) FGFR1ALDH1A1GABRA1GABRG2GABRB3
SCHEMBL2643844 0.78 GRM5 (0.53) CYP1A2MAPTCYP2C9CYP2C19PPP1CA
SCHEMBL2656192 0.77 IDO1 (0.49) MAPTKMT2ANPSR1FGFR1KDM4E
SCHEMBL2661511 0.75 DHFR (0.41) FGFR1ALDH1A1GABRA1GABRG2GABRB3
SCHEMBL2651810 0.75 MAPK1 (0.41) CYP1A2MAPTCYP2C9CYP2C19PPP1CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0821683-B1 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A RECEPTOR COMPLEX NEUROSEARCH AS (DK) 2006-11-02 EP claimed
US-5902813-A MODULATORS OF THE BENZODIAXEPINE RECEPTOR OT THE GAMMA-BUTYRIC ACID(A) RECEPTOR COMPLEX; ANXIOLYTIC, ANTIEPILEPTIC AND -CONVULSANT AGENTS; SLEEP AND MEMORY DISORDERS NEUROSEARCH A/S (DK) 1999-05-11 US claimed
EP-0821683-B1 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A RECEPTOR COMPLEX NEUROSEARCH AS (DK) 2006-11-02 EP disclosed
US-5902813-A MODULATORS OF THE BENZODIAXEPINE RECEPTOR OT THE GAMMA-BUTYRIC ACID(A) RECEPTOR COMPLEX; ANXIOLYTIC, ANTIEPILEPTIC AND -CONVULSANT AGENTS; SLEEP AND MEMORY DISORDERS NEUROSEARCH A/S (DK) 1999-05-11 US disclosed
EP-0821683-A1 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX NEUROSEARCH A/S (DK) 1998-02-04 EP disclosed
WO-1996033192-A1 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABAA RECEPTOR COMPLEX NEUROSEARCH A/S (DK) 1996-10-24 WO disclosed