Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 13/20 | 0.79 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.79 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.66 |
| ▸ | RAF1 | P04049 | 2/20 | 0.66 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.66 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.66 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.66 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2662559 | 0.89 | GCGR (1.00) | GCGRMAPK14MAPK13RAF1MAPK9 | |
| SCHEMBL2647604 | 0.82 | GCGR (1.00) | GCGRMAPK14 | |
| SCHEMBL6586611 | 0.82 | GCGR (0.86) | GCGRMAPK14 | |
| SCHEMBL21557189 | 0.82 | GCGR (1.00) | GCGRMAPK14MAPK13RAF1MAPK9 | |
| SCHEMBL8325229 | 0.80 | MAPK14 (1.00) | GCGRMAPK14MAPK13RAF1MAPK9 | |
| SCHEMBL2647090 | 0.80 | MAPK14 (0.75) | GCGRMAPK14MAPK13RAF1MAPK9 | |
| SCHEMBL13130596 | 0.80 | MAPK14 (0.75) | GCGRMAPK14MAPK13RAF1MAPK9 | |
| SCHEMBL8119445 | 0.80 | MAPK14 (0.75) | GCGRMAPK14MAPK13RAF1MAPK9 | |
| SCHEMBL8680959 | 0.79 | GCGR (0.79) | GCGRMAPK14 | |
| SCHEMBL5107178 | 0.77 | GCGR (0.76) | GCGRMAPK14MAPK13RAF1MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859771-A4 | SUBSTITUTED PYRIDYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2000-03-15 | — | — | EP | claimed |
| EP-0859771-A1 | SUBSTITUTED PYRIDYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck & Co., Inc. (US) | 1998-08-26 | — | — | EP | claimed |
| US-5776954-A | GLUCAGON ANTAGONISTS | MERCK & CO., INC. (US) | 1998-07-07 | — | — | US | claimed |
| WO-1997016442-A1 | SUBSTITUTED PYRIDYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 1997-05-09 | — | — | WO | claimed |