Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 1.00 |
| ▸ | MAPK13 | O15264 | 2/20 | 1.00 |
| ▸ | RAF1 | P04049 | 2/20 | 1.00 |
| ▸ | MAPK9 | P45984 | 2/20 | 1.00 |
| ▸ | MAPK12 | P53778 | 2/20 | 1.00 |
| ▸ | MAPK11 | Q15759 | 2/20 | 1.00 |
| ▸ | GCGR | P47871 | 13/20 | 0.75 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15070423 | 0.88 | MAPK14 (0.78) | MAPK14MAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL2662559 | 0.87 | GCGR (1.00) | MAPK14MAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL8322140 | 0.81 | MAPK14 (0.68) | MAPK14MAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL6586611 | 0.80 | GCGR (0.86) | MAPK14GCGR | |
| SCHEMBL2647604 | 0.80 | GCGR (1.00) | MAPK14GCGR | |
| SCHEMBL8119445 | 0.80 | MAPK14 (0.75) | MAPK14MAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL13130596 | 0.80 | MAPK14 (0.75) | MAPK14MAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL2647090 | 0.80 | MAPK14 (0.75) | MAPK14MAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL7841415 | 0.80 | MAPK13 (0.66) | MAPK14MAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL2647609 | 0.80 | GCGR (0.79) | MAPK14MAPK13RAF1MAPK9MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871444-A4 | 2,5-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 1999-01-13 | — | — | EP | claimed |
| EP-0871444-A1 | 2,5-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck & Co., Inc. (US) | 1998-10-21 | — | — | EP | claimed |
| WO-1997005878-A1 | 2,5-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 1997-02-20 | — | — | WO | claimed |
| US-5837719-A | USEFUL FOR TREATING CYTOKINE MEDIATED DISEASES, INFLAMMATION,SHOCK, ARTHRITIS, RESPIRATORY DISORDERS, THROMBOSIS, VIRAL INFECTION, GASTROINTESTINAL DISORDERS | MERCK & CO., INC. (US) | 1998-11-17 | — | — | US | disclosed |
| WO-1997005878-A1 | 2,5-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 1997-02-20 | — | — | WO | disclosed |