Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.63 |
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | HTT | P42858 | 4/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | GCGR | P47871 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2647267 | 0.85 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAHTTKMT2AMEN1 | |
| SCHEMBL2647305 | 0.84 | SMN1; SMN2 (0.62) | SMN1; SMN2LMNAHTTKMT2AMEN1 | |
| SCHEMBL15848539 | 0.82 | KMT2A (0.69) | SMN1; SMN2LMNAHTTKMT2AMEN1 | |
| SCHEMBL4253877 | 0.81 | POLB (0.64) | LMNAHTTKMT2AMEN1MAPT | |
| SCHEMBL11419693 | 0.81 | MAPT (0.70) | SMN1; SMN2LMNAHTTKMT2AMEN1 | |
| SCHEMBL22159634 | 0.81 | ROCK2 (0.58) | SMN1; SMN2LMNAHTTKMT2AMEN1 | |
| SCHEMBL15741784 | 0.78 | IMPDH2 (0.76) | SMN1; SMN2LMNAHTT | |
| SCHEMBL2655352 | 0.77 | KDM4E (0.45) | SMN1; SMN2LMNAHTTKMT2AMEN1 | |
| SCHEMBL4316986 | 0.76 | KMT2A (0.60) | SMN1; SMN2LMNAHTTKMT2AMEN1 | |
| SCHEMBL16632043 | 0.76 | MEN1 (0.54) | SMN1; SMN2LMNAHTTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613942-B1 | Nonpeptide; 4-hydroxy benzoic acid hydrazides | NOVO NORDISK A/S (DK) | 2003-09-02 | — | — | US | disclosed |
| EP-1140823-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039088-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2000-07-06 | — | — | WO | disclosed |