Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 18/20 | 0.47 |
| ▸ | TLR4 | O00206 | 1/20 | 0.41 |
| ▸ | TLR3 | O15455 | 1/20 | 0.41 |
| ▸ | TLR5 | O60602 | 1/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.41 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.41 |
| ▸ | CAMK1 | Q14012 | 1/20 | 0.41 |
| ▸ | CAMK4 | Q16566 | 1/20 | 0.41 |
| ▸ | PNCK | Q6P2M8 | 1/20 | 0.41 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.41 |
| ▸ | CAMK1G | Q96NX5 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654624 | 0.89 | GCGR (0.49) | GCGR | |
| SCHEMBL2650419 | 0.80 | PPIA (0.41) | BRD4 | |
| SCHEMBL2650428 | 0.77 | BRD4 (0.37) | GCGRBRD4 | |
| SCHEMBL2648040 | 0.76 | GCGR (0.42) | GCGRBRD4 | |
| SCHEMBL2647364 | 0.76 | GCGR (0.42) | GCGRBRD4 | |
| Formaldehyde SCHEMBL27525561 | 0.75 | TLR4 (0.43) | GCGRTLR4TLR3TLR5TLR2 | |
| SCHEMBL2646901 | 0.73 | GCGR (0.69) | GCGR | |
| SCHEMBL27525536 | 0.72 | GCGR (0.46) | GCGRTLR4TLR3TLR5TLR2 | |
| SCHEMBL2648334 | 0.71 | PTGER1 (0.45) | BRD4 | |
| SCHEMBL2650231 | 0.70 | PPIA (0.40) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218431-B1 | GLUCAGON RECEPTOR ANTAGONISTS FOR THERAPY OF DIABETES AND CONDITIONS ASSOCIATED WITH DIABETES | BAYER CORPORATION | 2001-04-17 | — | — | US | disclosed |