Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2648163 | 1.00 | ALDH1A1 (0.44) | ALDH1A1HSD17B10THRBATML3MBTL1 | |
| SCHEMBL27915029 | 0.82 | NPC1 (0.40) | ALDH1A1HTTMEN1KMT2AEPHX1 | |
| SCHEMBL27915038 | 0.82 | NPC1 (0.40) | ALDH1A1HTTMEN1KMT2AEPHX1 | |
| SCHEMBL2328813 | 0.82 | NPC1 (0.40) | ALDH1A1HTTMEN1KMT2AEPHX1 | |
| SCHEMBL13676856 | 0.82 | NPC1 (0.40) | ALDH1A1HTTMEN1KMT2AEPHX1 | |
| SCHEMBL27915075 | 0.82 | NPC1 (0.40) | ALDH1A1HTTMEN1KMT2AEPHX1 | |
| SCHEMBL2649659 | 0.80 | ALDH1A1 (0.52) | ALDH1A1HSD17B10THRBATML3MBTL1 | |
| SCHEMBL2647838 | 0.80 | ALDH1A1 (0.52) | ALDH1A1HSD17B10THRBATML3MBTL1 | |
| SCHEMBL2647840 | 0.80 | ALDH1A1 (0.52) | ALDH1A1HSD17B10THRBATML3MBTL1 | |
| SCHEMBL2649655 | 0.80 | ALDH1A1 (0.52) | ALDH1A1HSD17B10THRBATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582769-B2 | Dicycloalkyl urea glucokinase activators | NOVO NORDISK A/S (DK) | 2009-09-01 | — | — | US | disclosed |
| US-20090118501-A1 | Dicycloalkyl Urea Glucokinase Activators | NOVO NORDISK A/S (DK) | 2009-05-07 | — | — | US | disclosed |
| CN-101258137-A | Dicycloalkyl urea glucokinase activators | NOVO NORDISK AS (DK) | 2008-09-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118501-A1 | Dicycloalkyl Urea Glucokinase Activators | GCK, GCKR, UCK2 | ALDH1A1 3782/4885HSD17B10 1699/4885THRB 2429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.