Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 10/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 9/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.35 |
| ▸ | CDK1 | P06493 | 3/20 | 0.35 |
| ▸ | CDK4 | P11802 | 3/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.35 |
| ▸ | CCND1 | P24385 | 3/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | CDK9 | P50750 | 3/20 | 0.33 |
| ▸ | CIT | O14578 | 1/20 | 0.33 |
| ▸ | CASK | O14936 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | GAK | O14976 | 1/20 | 0.33 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.33 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2648401 | 1.00 | RAB9A (0.43) | RAB9ACDK2CCNE2CCNE1CCNB2 | |
| SCHEMBL2649005 | 0.99 | RAB9A (0.43) | RAB9ACDK2CCNE2CCNE1CCNB2 | |
| SCHEMBL2649008 | 0.99 | RAB9A (0.43) | RAB9ACDK2CCNE2CCNE1CCNB2 | |
| SCHEMBL2649802 | 0.94 | CDK2 (0.41) | RAB9ACDK2CCNE2CCNE1CCNB2 | |
| SCHEMBL1000423 | 0.91 | CDK2 (0.38) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL1000421 | 0.91 | CDK2 (0.38) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL2647706 | 0.89 | CCNE1 (0.36) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL2648978 | 0.89 | CCNE1 (0.36) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL2647707 | 0.89 | CCNE1 (0.36) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL2648983 | 0.89 | CCNE1 (0.36) | CDK2CCNE2CCNE1CCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582769-B2 | Dicycloalkyl urea glucokinase activators | NOVO NORDISK A/S (DK) | 2009-09-01 | — | — | US | disclosed |
| US-20090118501-A1 | Dicycloalkyl Urea Glucokinase Activators | NOVO NORDISK A/S (DK) | 2009-05-07 | — | — | US | disclosed |
| EP-1904466-A1 | DICYCLOALKYL UREA GLUCOKINASE ACTIVATORS | Novo Nordisk A/S (DK) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007006760-A1 | DICYCLOALKYL UREA GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118501-A1 | Dicycloalkyl Urea Glucokinase Activators | GCK, GCKR, UCK2 | RAB9A 2950/4885CDK2 253/4885CCNE2 2474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.