Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.43 |
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | CASP1 | P29466 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | KRAS | P01116 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20254478 | 0.70 | MAPT (0.49) | BPTFMETALDH1A1MAPTHSD17B10 | |
| SCHEMBL8281571 | 0.66 | MAPT (0.50) | ALDH1A1MAPTHSD17B10GAAALOX15 | |
| SCHEMBL2658305 | 0.66 | ALDH1A1 (0.47) | BPTFALDH1A1MAPTHSD17B10GAA | |
| SCHEMBL12643259 | 0.63 | BPTF (0.39) | BPTFMETALDH1A1MAPTHSD17B10 | |
| SCHEMBL620749 | 0.62 | BPTF (1.00) | BPTFALDH1A1MAPTHSD17B10GAA | |
| SCHEMBL1514467 | 0.62 | BPTF (0.92) | BPTFALDH1A1MAPTHSD17B10GAA | |
| SCHEMBL27855310 | 0.62 | ALDH1A1 (0.43) | ALDH1A1MAPTHSD17B10GAAALOX15 | |
| SCHEMBL31381502 | 0.61 | BPTF (0.96) | BPTFALDH1A1MAPTHSD17B10GAA | |
| SCHEMBL1719516 | 0.61 | ALDH1A1 (1.00) | BPTFALDH1A1MAPTHSD17B10GAA | |
| SCHEMBL31684745 | 0.61 | IGF1R (0.47) | ALOX15MAPK1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060035958-A1 | Method of treating diabetes and related conditions | MERCK & CO., INC. | 2006-02-16 | — | — | US | disclosed |
| EP-1538903-A2 | METHOD OF TREATING DIABETES AND RELATED CONDITIONS | Merck & Co., Inc. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004024066-A2 | METHOD OF TREATING DIABETES AND RELATED CONDITIONS | MERCK & CO., INC. (US) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035958-A1 | Method of treating diabetes and related conditions | GLP1R, GPR119, GCGR | BPTF 4242/4885MET 1026/4885ALDH1A1 2972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.