Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 20/20 | 0.67 |
| ▸ | GABRB3 | P28472 | 20/20 | 0.67 |
| ▸ | GABRA3 | P34903 | 20/20 | 0.67 |
| ▸ | GABRA1 | P14867 | 14/20 | 0.67 |
| ▸ | GABRA2 | P47869 | 11/20 | 0.67 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7868704 | 0.88 | GABRG2 (0.56) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL340792 | 0.87 | GABRG2 (0.73) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341822 | 0.85 | GABRG2 (0.71) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL342006 | 0.85 | GABRG2 (0.71) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2650885 | 0.85 | GABRG2 (0.56) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2650038 | 0.83 | GABRG2 (0.57) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL5784176 | 0.82 | GABRG2 (0.71) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7860979 | 0.82 | GABRG2 (0.64) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7860974 | 0.81 | GABRG2 (0.57) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7865969 | 0.81 | GABRA1 (0.57) | GABRG2GABRB3GABRA3GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303597-B1 | FOR THERAPY OF ANXIETY AND CONVULSIONS | MERCK SHARP & DOHME LIMITED (GB) | 2001-10-16 | — | — | US | claimed |
| EP-1047697-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2000-11-02 | — | — | EP | claimed |
| WO-1999036423-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1999-07-22 | — | — | WO | claimed |
| US-6303597-B1 | FOR THERAPY OF ANXIETY AND CONVULSIONS | MERCK SHARP & DOHME LIMITED (GB) | 2001-10-16 | — | — | US | disclosed |